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Dnase2a deoxyribonuclease II alpha [ Mus musculus (house mouse) ]

Gene ID: 13423, updated on 27-Feb-2024

Summary

Official Symbol
Dnase2aprovided by MGI
Official Full Name
deoxyribonuclease II alphaprovided by MGI
Primary source
MGI:MGI:1329019
See related
Ensembl:ENSMUSG00000003812 AllianceGenome:MGI:1329019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dnase2
Summary
Enables deoxyribonuclease II activity. Acts upstream of or within DNA catabolic process, endonucleolytic; erythrocyte differentiation; and regulation of immune response. Predicted to be located in lysosome. Is expressed in olfactory epithelium and vibrissa. Used to study rheumatoid arthritis. Orthologous to human DNASE2 (deoxyribonuclease 2, lysosomal). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 17.4), mammary gland adult (RPKM 14.9) and 26 other tissues See more
Orthologs
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Genomic context

See Dnase2a in Genome Data Viewer
Location:
8 C3; 8 41.31 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85635384..85638332)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84908755..84911703)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1763 Neighboring gene glutaryl-Coenzyme A dehydrogenase Neighboring gene predicted gene, 39213 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87427053-87427162 Neighboring gene STARR-positive B cell enhancer ABC_E1373 Neighboring gene Kruppel-like transcription factor 1 (erythroid) Neighboring gene predicted gene, 38426 Neighboring gene microtubule associated serine/threonine kinase 1 Neighboring gene retbindin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables deoxyribonuclease II activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables deoxyribonuclease II activity IDA
Inferred from Direct Assay
more info
PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within enucleate erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in lysosome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
deoxyribonuclease-2-alpha
Names
DNase II alpha
acid DNase
lysosomal DNase II
NP_001355224.1
NP_001355225.1
NP_034192.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368295.1NP_001355224.1  deoxyribonuclease-2-alpha isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC161765
  2. NM_001368296.1NP_001355225.1  deoxyribonuclease-2-alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161765
    Consensus CDS
    CCDS90428.1
    UniProtKB/TrEMBL
    D3Z512
    Related
    ENSMUSP00000105366.2, ENSMUST00000109744.8
  3. NM_010062.4NP_034192.1  deoxyribonuclease-2-alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_034192.1

    Status: VALIDATED

    Source sequence(s)
    AC161765
    Consensus CDS
    CCDS22484.1
    UniProtKB/Swiss-Prot
    O55053, P56542
    UniProtKB/TrEMBL
    Q3UM14
    Related
    ENSMUSP00000003910.7, ENSMUST00000003910.13
    Conserved Domains (2) summary
    pfam03265
    Location:21346
    DNase_II; Deoxyribonuclease II
    cl15239
    Location:19178
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85635384..85638332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)