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Dnase2a deoxyribonuclease II alpha [ Mus musculus (house mouse) ]

Gene ID: 13423, updated on 4-Sep-2018

Summary

Official Symbol
Dnase2aprovided by MGI
Official Full Name
deoxyribonuclease II alphaprovided by MGI
Primary source
MGI:MGI:1329019
See related
Ensembl:ENSMUSG00000003812 Vega:OTTMUSG00000022266
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dnase2
Expression
Ubiquitous expression in spleen adult (RPKM 17.4), mammary gland adult (RPKM 14.9) and 26 other tissues See more
Orthologs

Genomic context

See Dnase2a in Genome Data Viewer
Location:
8 C3; 8 41.31 cM
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (84908624..84911461)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (87432523..87435360)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39213 Neighboring gene Kruppel-like factor 1 (erythroid) Neighboring gene predicted gene, 38426 Neighboring gene microtubule associated serine/threonine kinase 1 Neighboring gene retbindin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
deoxyribonuclease II activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
deoxyribonuclease II activity IDA
Inferred from Direct Assay
more info
PubMed 
endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA catabolic process, endonucleolytic IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
lysosome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
deoxyribonuclease-2-alpha
Names
DNase II alpha
acid DNase
lysosomal DNase II
NP_034192.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010062.3NP_034192.1  deoxyribonuclease-2-alpha precursor

    See identical proteins and their annotated locations for NP_034192.1

    Status: PROVISIONAL

    Source sequence(s)
    AK145192, BQ829838, BY757082
    Consensus CDS
    CCDS22484.1
    UniProtKB/Swiss-Prot
    P56542
    UniProtKB/TrEMBL
    Q3UM14
    Related
    ENSMUSP00000003910.6, OTTMUSP00000025187, ENSMUST00000003910.12, OTTMUST00000053020
    Conserved Domains (2) summary
    pfam03265
    Location:21346
    DNase_II; Deoxyribonuclease II
    cl15239
    Location:19178
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    84908624..84911461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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