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IRF1 interferon regulatory factor 1 [ Gallus gallus (chicken) ]

Gene ID: 396384, updated on 6-Jun-2024

Summary

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Symbol
IRF1provided by CGNC
Full Name
interferon regulatory factor 1provided by CGNC
Primary source
CGNC:5120
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See IRF1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
11
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 13 NC_052544.1 (16493644..16499641, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 13 NC_052585.1 (16505431..16511434, complement)

Chromosome 13 - NC_052544.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 4 Neighboring gene microRNA 1609-1 Neighboring gene solute carrier family 22 member 5 Neighboring gene interleukin 5 Neighboring gene RAD50 double strand break repair protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chicken interferon regulatory factor 1 (IRF1) involved in antiviral innate immunity via regulating IFN-β production. Liu Y, et al. Dev Comp Immunol, 2018 Nov. PMID 29981306
  2. Chicken interferon consensus sequence-binding protein (ICSBP) and interferon regulatory factor (IRF) 1 genes reveal evolutionary conservation in the IRF gene family. Jungwirth C, et al. Proc Natl Acad Sci U S A, 1995 Apr 11. PMID 7536924, Free PMC Article
  3. Characterization of the first nonmammalian T2 cytokine gene cluster: the cluster contains functional single-copy genes for IL-3, IL-4, IL-13, and GM-CSF, a gene for IL-5 that appears to be a pseudogene, and a gene encoding another cytokinelike transcript, KK34. Avery S, et al. J Interferon Cytokine Res, 2004 Oct. PMID 15626157
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBE2J1 promotes ALV-A proviral DNA synthesis through the STAT3/IRF1 signaling pathway.
    Title: UBE2J1 promotes ALV-A proviral DNA synthesis through the STAT3/IRF1 signaling pathway.
  2. these studies demonstrate that chIRF1 is an important regulator of IFN-beta and is involved in chicken antiviral innate immunity.
    Title: Chicken interferon regulatory factor 1 (IRF1) involved in antiviral innate immunity via regulating IFN-β production.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interferon regulatory factor 1
Names
IRF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205415.2 → NP_990746.1  interferon regulatory factor 1

    See identical proteins and their annotated locations for NP_990746.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000256
    UniProtKB/Swiss-Prot
    Q5W4T4, Q90876
    UniProtKB/TrEMBL
    A0A8V0YVG0, M4M675
    Conserved Domains (1) summary
    pfam00605
    Location:7 → 112
    IRF; Interferon regulatory factor transcription factor

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    16493644..16499641 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015294015.3 → XP_015149501.2  interferon regulatory factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YVG0
    Conserved Domains (1) summary
    cd00103
    Location:5 → 113
    IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...

  2. XM_046900312.1 → XP_046756268.1  interferon regulatory factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5W4T4, Q90876
    UniProtKB/TrEMBL
    A0A8V0YVG0, M4M675

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    16505431..16511434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046926881.1 → XP_046782837.1  interferon regulatory factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YVG0

  2. XM_046926880.1 → XP_046782836.1  interferon regulatory factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5W4T4, Q90876
    UniProtKB/TrEMBL
    A0A8V0YVG0, M4M675
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90876.1 GenPept UniProtKB/Swiss-Prot:Q90876

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials