Format

Send to:

Choose Destination

Irf1 interferon regulatory factor 1 [ Mus musculus (house mouse) ]

Gene ID: 16362, updated on 9-Sep-2018

Summary

Official Symbol
Irf1provided by MGI
Official Full Name
interferon regulatory factor 1provided by MGI
Primary source
MGI:MGI:96590
See related
Ensembl:ENSMUSG00000018899 Vega:OTTMUSG00000005648
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Irf-1; AU020929
Expression
Broad expression in large intestine adult (RPKM 53.2), colon adult (RPKM 41.6) and 20 other tissues See more
Orthologs

Genomic context

See Irf1 in Genome Data Viewer
Location:
11 B1.3; 11 32.0 cM
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (53770014..53778374)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (53583516..53591876)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene interleukin 5 Neighboring gene microRNA 7671 Neighboring gene predicted gene 12216 Neighboring gene predicted gene, 30785 Neighboring gene solute carrier family 22 (organic cation transporter), member 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
CD8-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
cellular response to peptide hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to virus ISO
Inferred from Sequence Orthology
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
interferon-gamma-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T-helper 2 cell differentiation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T-helper 1 cell differentiation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-12 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-12 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of natural killer cell differentiation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of CD8-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of MyD88-dependent toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of adaptive immune response TAS
Traceable Author Statement
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of immune response IEA
Inferred from Electronic Annotation
more info
 
regulation of innate immune response TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to growth hormone ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interferon regulatory factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159393.1NP_001152865.1  interferon regulatory factor 1 isoform b

    See identical proteins and their annotated locations for NP_001152865.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK152193, BY266109
    Consensus CDS
    CCDS48796.1
    UniProtKB/TrEMBL
    Q3U5M1
    Related
    ENSMUSP00000104550.1, OTTMUSP00000019805, ENSMUST00000108922.7, OTTMUST00000044065
    Conserved Domains (1) summary
    pfam00605
    Location:7112
    IRF; Interferon regulatory factor transcription factor
  2. NM_001159396.1NP_001152868.1  interferon regulatory factor 1 isoform a

    See identical proteins and their annotated locations for NP_001152868.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' non-coding exon, compared to variant 1, and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK152005, BE950981, BY328342
    Consensus CDS
    CCDS24686.1
    UniProtKB/Swiss-Prot
    P15314
    UniProtKB/TrEMBL
    Q5SX13
    Related
    ENSMUSP00000019043.6, OTTMUSP00000005821, ENSMUST00000019043.12, OTTMUST00000012564
    Conserved Domains (1) summary
    pfam00605
    Location:7112
    IRF; Interferon regulatory factor transcription factor
  3. NM_008390.2NP_032416.1  interferon regulatory factor 1 isoform a

    See identical proteins and their annotated locations for NP_032416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK152005, BE950981, BY266109
    Consensus CDS
    CCDS24686.1
    UniProtKB/Swiss-Prot
    P15314
    UniProtKB/TrEMBL
    Q5SX13
    Related
    ENSMUSP00000104548.2, OTTMUSP00000005820, ENSMUST00000108920.8, OTTMUST00000012563
    Conserved Domains (1) summary
    pfam00605
    Location:7112
    IRF; Interferon regulatory factor transcription factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    53770014..53778374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center