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Hsp67Ba Heat shock gene 67Ba [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39076, updated on 18-Sep-2024

Summary

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Official Symbol
Hsp67Baprovided by FlyBase
Official Full Name
Heat shock gene 67Baprovided by FlyBase
Primary source
FLYBASE:FBgn0001227
Locus tag
Dmel_CG4167
See related
AllianceGenome:FB:FBgn0001227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4167; Dmel22.2; Dmel\CG4167; DmHsp67; DROHSP; DROHSP1; gene 1; gene1; Hsp-G1; hsp67Ba; HSP67BA; small hsp locus 67B
Summary
Predicted to enable unfolded protein binding activity. Involved in response to heat. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1) and HSPB2 (heat shock protein family B (small) member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
67B2-67B2; 3-29 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9377802..9379534, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9370902..9372634, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 26 Neighboring gene antisense RNA:CR43481 Neighboring gene Heat shock protein 23 Neighboring gene Heat shock protein 27 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple interacting elements delineate an ecdysone-dependent regulatory region with secondary responsive character. Rogulski KR, et al. J Mol Biol, 1995 Jun 2. PMID 7783195
  2. Characterization of the shsp genes in Drosophila buzzatii and association between the frequency of Valine mutations in hsp23 and climatic variables along a longitudinal gradient in Australia. Frydenberg J, et al. Cell Stress Chaperones, 2010 May. PMID 19806471, Free PMC Article
  3. Small heat shock protein Hsp67Bc plays a significant role in Drosophila melanogaster cold stress tolerance. Malkeyeva D, et al. J Exp Biol, 2020 Nov 2. PMID 32943578
  4. Locus 67B of Drosophila melanogaster contains seven, not four, closely related heat shock genes. Ayme A, et al. EMBO J, 1985 Nov. PMID 3933974, Free PMC Article
  5. A Drosophila heat shock gene from locus 67B is expressed during embryogenesis and pupation. Pauli D, et al. J Mol Biol, 1987 Nov 20. PMID 3123699

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to heat IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
heat shock gene 67Ba
Names
CG4167-PA
Hsp67Ba-PA
gene 1
heat shock protein family B (small) member 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9377802..9379534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079274.3 → NP_523998.1  heat shock gene 67Ba [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523998.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P05812, Q5U130, Q9VSX4
    Related
    FBpp0076223
    Conserved Domains (2) summary
    cd06526
    Location:124 → 200
    metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
    cl26247
    Location:218 → 381
    DNA_pol3_delta2; DNA polymerase III, delta subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05812.2 P05812

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