Dhc64C Dynein heavy chain 64C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dhc64Cprovided by FlyBase
Official Full Name: Dynein heavy chain 64Cprovided by FlyBase
Primary source: FLYBASE:FBgn0261797
Locus tag: Dmel_CG7507
See related: AllianceGenome:FB:FBgn0261797
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CD; cDhc; Cdhc; cDhc64C; CG7507; dhc; Dhc; DHC; Dhc 64C; DHC1; Dhc46C; dhc64; Dhc64; dhc64c; dhc64C; Dhc64c; DHC64C; Dmel\CG7507; DYHC; dynein; Dynein; FCP-A; Fs(3)Lab; Fs(3)Laborc; Fs(3)Sz18; HMW MAP; l(3)64Ca; Lab; Su(Gl)77
Summary: Enables microtubule motor activity. Involved in several processes, including gamete generation; microtubule cytoskeleton organization; and nervous system development. Located in several cellular components, including Golgi apparatus; axon cytoplasm; and kinetochore. Part of dynein complex and ribonucleoprotein complex. Is expressed in adult head; adult heart; and gonad. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2O; autosomal dominant non-syndromic intellectual disability 13; and spinal muscular atrophy with lower extremity predominance 1. Orthologous to human DYNC1H1 (dynein cytoplasmic 1 heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 64B17-64C1; 3-13 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4807368..4825687, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4807368..4825687, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor.
Title: In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor.
A new mode of mitochondrial sorting in polarized cell growth, whereby bi-directional mitochondrial transport undertaken exclusively by dynein is regulated by Milton in the anterograde direction and by a Miro-dependent switch to the retrograde direction.
Title: A new mode of mitochondrial transport and polarized sorting regulated by Dynein, Milton and Miro.
Dynein knockdown prevents this rearrangement and results in microtubules of mixed orientation in axons and accumulation of microtubule minus-ends at axon tips.
Title: Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons.
Apical enrichment of recycling endosomes is dependent on the MT motor Dynein and is essential for the function of this vesicular compartment.
Title: Microtubule-dependent apical restriction of recycling endosomes sustains adherens junctions during morphogenesis of the Drosophila tracheal system.
data implicate Kinesin and Dynein in two distinct and independently regulated mechanisms of moving myonuclei, which together maximize the ability of myonuclei to achieve their proper localizations within the constraints imposed by embryonic development
Title: Translocating myonuclei have distinct leading and lagging edges that require kinesin and dynein.
The data reveal a critical role for Lis1 within the mRNA localization machinery and suggest a model in which Lis1 facilitates motor complex association with cargos by promoting the interaction of dynein with dynactin.
Title: Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAs.
A general role of Lis-1/NudE, Dynein and microtubules, in cell-on-cell migration, is reported.
Title: Microtubules and Lis-1/NudE/dynein regulate invasive cell-on-cell migration in Drosophila.
Dynein-mediated messenger RNA transport coupled with a localized translation mechanism is involved in localizing Crumbs to the apical domain to mediate epithelial apicobasal polarity
Title: Dynein-mediated apical localization of crumbs transcripts is required for Crumbs activity in epithelial polarity.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables dynein intermediate chain binding	ISS Inferred from Sequence or Structural Similarity more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables minus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables minus-end-directed microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables minus-end-directed microtubule motor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axo-dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellularization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chitin-based cuticle development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cystoblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of Golgi localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of epithelial cell apical/basal polarity	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of mitotic spindle localization	TAS Traceable Author Statement more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fusome organization	TAS Traceable Author Statement more info	PubMed
involved_in germ-line cyst formation	TAS Traceable Author Statement more info	PubMed
involved_in germarium-derived oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular mRNA localization	TAS Traceable Author Statement more info	PubMed
involved_in intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lumen formation, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of RNA location	IDA Inferred from Direct Assay more info	PubMed
involved_in melanotic encapsulation of foreign target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion distribution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in oocyte nucleus migration involved in oocyte dorsal/ventral axis specification	TAS Traceable Author Statement more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian fusome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole cell formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic centrosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic metaphase/anaphase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde axonal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde axonal transport of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress granule assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in axon cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
part_of dynein complex	IPI Inferred from Physical Interaction more info	PubMed
located_in fusome	TAS Traceable Author Statement more info	PubMed
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
part_of microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed
located_in posterior cell cortex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dynein heavy chain 64C

Names: CG7507-PA; CG7507-PC; CG7507-PD; CG7507-PE; CG7507-PF; CG7507-PG; CG7507-PH; CG7507-PI; Dhc64C-PA; Dhc64C-PC; Dhc64C-PD; Dhc64C-PE; Dhc64C-PF; Dhc64C-PG; Dhc64C-PH; Dhc64C-PI; cytoplasmic dynein; cytoplasmic dynein heavy chain; cytoplasmic dynenin; dynein; dynein HC; dynein heavy chain; dynein heavy chain 64c; dynein heavy chain at 64C; dynein heavy-chain; female sterile(3)Laborc; laborc; suppressor of glued 77

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

4807368..4825687 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274501.1 → NP_001261430.1 dynein heavy chain 64C, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261430.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEC8

Conserved Domains (8) summary

COG5245
Location:1009 → 4325

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam03028
Location:3912 → 4623

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08385
Location:240 → 826

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:1313 → 1711

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12777
Location:3195 → 3531

MT; Microtubule-binding stalk of dynein motor

pfam12781
Location:3556 → 3771

AAA_9; ATP-binding dynein motor region D5

cl00641
Location:2821 → 2930

Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4

cl21455
Location:1857 → 2090

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001274498.1 → NP_001261427.1 dynein heavy chain 64C, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261427.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBQ0

Conserved Domains (8) summary

COG5245
Location:1022 → 4328

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam03028
Location:3915 → 4626

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08385
Location:240 → 839

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:1326 → 1724

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12777
Location:3199 → 3534

MT; Microtubule-binding stalk of dynein motor

pfam12781
Location:3559 → 3774

AAA_9; ATP-binding dynein motor region D5

cl00641
Location:2825 → 2934

Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4

cl21455
Location:1870 → 2103

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001274503.1 → NP_001261432.1 dynein heavy chain 64C, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261432.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBQ3

Conserved Domains (8) summary

COG5245
Location:1022 → 4338

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam03028
Location:3925 → 4636

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08385
Location:240 → 839

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:1326 → 1724

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12777
Location:3208 → 3544

MT; Microtubule-binding stalk of dynein motor

pfam12781
Location:3569 → 3784

AAA_9; ATP-binding dynein motor region D5

cl00641
Location:2834 → 2943

Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4

cl21455
Location:1870 → 2103

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001274502.1 → NP_001261431.1 dynein heavy chain 64C, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261431.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PHG8

Conserved Domains (8) summary

COG5245
Location:1022 → 4337

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam03028
Location:3924 → 4635

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08385
Location:240 → 839

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:1326 → 1724

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12777
Location:3208 → 3543

MT; Microtubule-binding stalk of dynein motor

pfam12781
Location:3568 → 3783

AAA_9; ATP-binding dynein motor region D5

cl00641
Location:2834 → 2943

Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4

cl21455
Location:1870 → 2103

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_079205.4 → NP_523929.2 dynein heavy chain 64C, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523929.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P37276, Q8IRA5, Q961M8, Q9VZ83

Related

FBpp0073215

Conserved Domains (8) summary

COG5245
Location:1009 → 4316

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam03028
Location:3903 → 4614

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08385
Location:240 → 826

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:1313 → 1711

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12777
Location:3186 → 3522

MT; Microtubule-binding stalk of dynein motor

pfam12781
Location:3547 → 3762

AAA_9; ATP-binding dynein motor region D5

cl00641
Location:2812 → 2921

Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4

cl21455
Location:1857 → 2090

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_168103.3 → NP_729034.2 dynein heavy chain 64C, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729034.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P37276

Conserved Domains (8) summary

COG5245
Location:1009 → 4315

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam03028
Location:3902 → 4613

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08385
Location:240 → 826

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:1313 → 1711

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12777
Location:3186 → 3521

MT; Microtubule-binding stalk of dynein motor

pfam12781
Location:3546 → 3761

AAA_9; ATP-binding dynein motor region D5

cl00641
Location:2812 → 2921

Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4

cl21455
Location:1857 → 2090

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001274499.1 → NP_001261428.1 dynein heavy chain 64C, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261428.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PE73

Conserved Domains (8) summary

COG5245
Location:1009 → 4324

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam03028
Location:3911 → 4622

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08385
Location:240 → 826

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:1313 → 1711

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12777
Location:3195 → 3530

MT; Microtubule-binding stalk of dynein motor

pfam12781
Location:3555 → 3770

AAA_9; ATP-binding dynein motor region D5

cl00641
Location:2821 → 2930

Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4

cl21455
Location:1857 → 2090

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001274500.1 → NP_001261429.1 dynein heavy chain 64C, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261429.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEN4

Conserved Domains (8) summary

COG5245
Location:1022 → 4329

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam03028
Location:3916 → 4627

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08385
Location:240 → 839

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:1326 → 1724

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12777
Location:3199 → 3535

MT; Microtubule-binding stalk of dynein motor

pfam12781
Location:3560 → 3775

AAA_9; ATP-binding dynein motor region D5

cl00641
Location:2825 → 2934

Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4

cl21455
Location:1870 → 2103

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases