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ILK integrin linked kinase [ Gallus gallus (chicken) ]

Gene ID: 374018, updated on 17-Aug-2024

Summary

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Symbol
ILKprovided by CGNC
Full Name
integrin linked kinaseprovided by CGNC
Primary source
CGNC:13025
See related
Ensembl:ENSGALG00010001689
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
ILK1; ILK2; ILK-1; ILK-2; p59ILK
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
13
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (196192365..196197794)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (196063957..196069385)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor interacting protein 2 Neighboring gene translocase of inner mitochondrial membrane 10B Neighboring gene F-box/WD repeat-containing protein 7 Neighboring gene ribosomal RNA processing 8 Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene tripeptidyl peptidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ca2+-independent smooth muscle contraction. a novel function for integrin-linked kinase. Deng JT, et al. J Biol Chem, 2001 May 11. PMID 11278951
  2. Integrin-Linked Kinase (ILK) Plays an Important Role in the Laminin-Dependent Development of Dorsal Root Ganglia during Chicken Embryogenesis. Mrówczyńska E, et al. Cells, 2021 Jul 2. PMID 34359835, Free PMC Article
  3. Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog. Guo D, et al. Mol Cell Neurosci, 2012 May. PMID 22521536, Free PMC Article
  4. Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. Persad S, et al. J Biol Chem, 2001 Jul 20. PMID 11313365
  5. ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling. Qian Y, et al. Oncogene, 2005 Apr 28. PMID 15735674

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Integrin-Linked Kinase (ILK) Plays an Important Role in the Laminin-Dependent Development of Dorsal Root Ganglia during Chicken Embryogenesis.
    Title: Integrin-Linked Kinase (ILK) Plays an Important Role in the Laminin-Dependent Development of Dorsal Root Ganglia during Chicken Embryogenesis.
  2. ILK with the PKCalpha phosphorylation sites mutated disrupts RGC axon pathfinding at the optic chiasm.
    Title: Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog.
  3. ILK regulates both integrin-associated rearrangements of actin filaments and cell migration and invasion at the integrin receptor-proximal region
    Title: ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
integrin-linked protein kinase
Names
59 kDa serine/threonine-protein kinase
beta-integrin-linked kinase
NP_989525.1
XP_046762285.1
XP_046796489.1
XP_046796518.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204194.2 → NP_989525.1  integrin-linked protein kinase

    See identical proteins and their annotated locations for NP_989525.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000032
    UniProtKB/Swiss-Prot
    Q9DF58
    UniProtKB/TrEMBL
    A0A8V0X355
    Related
    ENSGALP00010002177.1, ENSGALT00010003873.1
    Conserved Domains (4) summary
    cd14057
    Location:197 → 449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:33 → 64
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:4 → 54
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:38 → 124
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    196192365..196197794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046940533.1 → XP_046796489.1  integrin-linked protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8V0X355

  2. XM_046940562.1 → XP_046796518.1  integrin-linked protein kinase isoform X2

    UniProtKB/TrEMBL
    A0A8V0X9J6
    Related
    ENSGALP00010002181.1, ENSGALT00010003877.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    196063957..196069385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906329.1 → XP_046762285.1  integrin-linked protein kinase isoform X3

    UniProtKB/TrEMBL
    A0A8V0X355
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DF58.1 GenPept UniProtKB/Swiss-Prot:Q9DF58

Gene LinkOut

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Molecular Biology Databases
Research Materials