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ILK integrin linked kinase [ Homo sapiens (human) ]

Gene ID: 3611, updated on 17-Jun-2018
Official Symbol
ILKprovided by HGNC
Official Full Name
integrin linked kinaseprovided by HGNC
Primary source
HGNC:HGNC:6040
See related
Ensembl:ENSG00000166333 MIM:602366; Vega:OTTHUMG00000133407
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P59; ILK-1; ILK-2; p59ILK; HEL-S-28
Summary
This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in endometrium (RPKM 90.1), prostate (RPKM 80.8) and 25 other tissues See more
Orthologs
See ILK in Genome Data Viewer
Location:
11p15.4
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (6603708..6610874)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6624938..6632105)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene voltage dependent anion channel 1 pseudogene Neighboring gene dynein heavy chain domain 1 Neighboring gene ribosomal RNA processing 8 Neighboring gene uncharacterized LOC107984305 Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene tripeptidyl peptidase 1 Neighboring gene dachsous cadherin-related 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
    Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
    Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • Cell junction organization, organism-specific biosystem (from REACTOME)
    Cell junction organization, organism-specific biosystem
    Cell junction organization
  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
  • Cell-extracellular matrix interactions, organism-specific biosystem (from REACTOME)
    Cell-extracellular matrix interactions, organism-specific biosystemCell-extracellular matrix (ECM) interactions play a critical role in regulating a variety of cellular processes in multicellular organisms including motility, shape change, survival, proliferation an...
  • Endometrial cancer, organism-specific biosystem (from KEGG)
    Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
  • Endometrial cancer, conserved biosystem (from KEGG)
    Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
  • Eukaryotic Transcription Initiation, organism-specific biosystem (from WikiPathways)
    Eukaryotic Transcription Initiation, organism-specific biosystemIn eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the pre...
  • Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, organism-specific biosystem (from WikiPathways)
    Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, organism-specific biosystemThe signaling pathway that involves insulin-like growth factor 1 (IGF1), and a variety of other components that affect the pathway, plays an important role in the regulation of skeletal muscle growth...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
  • Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
    Integrins in angiogenesis, organism-specific biosystem
    Integrins in angiogenesis
  • Localization of the PINCH-ILK-PARVIN complex to focal adhesions, organism-specific biosystem (from REACTOME)
    Localization of the PINCH-ILK-PARVIN complex to focal adhesions, organism-specific biosystemThe interactions among ILK, PINCH, and parvins are necessary but not sufficient for localization of ILK to cell-ECM adhesions (Zhang et al., 2002). Additional proteins that interact with PINCH-IL...
  • Osteopontin-mediated events, organism-specific biosystem (from Pathway Interaction Database)
    Osteopontin-mediated events, organism-specific biosystem
    Osteopontin-mediated events
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystem (from WikiPathways)
    Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystemPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) a cause of nephrotic syndrome in children and adolescents, as well as an important cause of end stage renal disease in adults. FSGS is ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686F1765

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell aging IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
cell junction assembly TAS
Traceable Author Statement
more info
 
cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion TAS
Traceable Author Statement
more info
PubMed 
establishment or maintenance of epithelial cell apical/basal polarity IEA
Inferred from Electronic Annotation
more info
 
fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myelin assembly IEA
Inferred from Electronic Annotation
more info
 
myelination in peripheral nervous system IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
nerve development IEA
Inferred from Electronic Annotation
more info
 
neuron projection morphogenesis IEA
Inferred from Electronic Annotation
more info
 
outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
platelet aggregation HMP PubMed 
positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein heterooligomerization IEA
Inferred from Electronic Annotation
more info
 
protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
supramolecular fiber organization IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
costamere IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendritic shaft IEA
Inferred from Electronic Annotation
more info
 
focal adhesion HDA PubMed 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
sarcomere IEA
Inferred from Electronic Annotation
more info
 
COLOCALIZES_WITH stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
integrin-linked protein kinase
Names
59 kDa serine/threonine-protein kinase
epididymis secretory protein Li 28
integrin-linked kinase-2
NP_001014794.1
NP_001014795.1
NP_001265370.1
NP_001265371.1
NP_004508.1
XP_005252961.1
XP_005252962.1
XP_011518367.1
XP_016873161.1
XP_024304262.1
XP_024304263.1
XP_024304264.1
XP_024304265.1
XP_024304266.1
XP_024304267.1
XP_024304268.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029702.1 RefSeqGene

    Range
    4975..12142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_444

mRNA and Protein(s)

  1. NM_001014794.2NP_001014794.1  integrin-linked protein kinase isoform 1

    See identical proteins and their annotated locations for NP_001014794.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    BC001554, DC380243, HY257434, U40282
    Consensus CDS
    CCDS7768.1
    UniProtKB/Swiss-Prot
    Q13418
    UniProtKB/TrEMBL
    V9HWF0
    Related
    ENSP00000403487.2, OTTHUMP00000229991, ENST00000420936.6, OTTHUMT00000384513
    Conserved Domains (3) summary
    cd00204
    Location:28140
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:197449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
  2. NM_001014795.2NP_001014795.1  integrin-linked protein kinase isoform 1

    See identical proteins and their annotated locations for NP_001014795.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    CR749220, DC379936, HY257434, U40282
    Consensus CDS
    CCDS7768.1
    UniProtKB/Swiss-Prot
    Q13418
    UniProtKB/TrEMBL
    V9HWF0
    Related
    ENSP00000379975.2, OTTHUMP00000229996, ENST00000396751.6, OTTHUMT00000384519
    Conserved Domains (3) summary
    cd00204
    Location:28140
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:197449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
  3. NM_001278441.1NP_001265370.1  integrin-linked protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001265370.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons in the coding region, which results in a section that contains a frameshift, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC091564, AK296628, DC380243, HY257434, U40282
    Consensus CDS
    CCDS60712.1
    UniProtKB/Swiss-Prot
    Q13418
    Related
    ENSP00000435323.1, OTTHUMP00000229995, ENST00000528995.5, OTTHUMT00000384517
    Conserved Domains (3) summary
    cd00204
    Location:28117
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:144388
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
  4. NM_001278442.1NP_001265371.1  integrin-linked protein kinase isoform 3

    See identical proteins and their annotated locations for NP_001265371.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, lacks an exon in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK293474, DC380243, HY257434
    Consensus CDS
    CCDS60713.1
    UniProtKB/Swiss-Prot
    Q13418
    Related
    ENSP00000434492.2, ENST00000532063.5
    Conserved Domains (1) summary
    cd14057
    Location:63315
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
  5. NM_004517.3NP_004508.1  integrin-linked protein kinase isoform 1

    See identical proteins and their annotated locations for NP_004508.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    DC380243, HY257434, U40282
    Consensus CDS
    CCDS7768.1
    UniProtKB/Swiss-Prot
    Q13418
    UniProtKB/TrEMBL
    V9HWF0
    Related
    ENSP00000299421.3, OTTHUMP00000164591, ENST00000299421.8, OTTHUMT00000257264
    Conserved Domains (3) summary
    cd00204
    Location:28140
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:197449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    6603708..6610874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448499.1XP_024304267.1  integrin-linked protein kinase isoform X3

  2. XM_017017672.1XP_016873161.1  integrin-linked protein kinase isoform X3

    Conserved Domains (3) summary
    cd00204
    Location:289
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:146398
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:1546
    ANK; ANK repeat [structural motif]
  3. XM_005252904.5XP_005252961.1  integrin-linked protein kinase isoform X2

    See identical proteins and their annotated locations for XP_005252961.1

    UniProtKB/Swiss-Prot
    Q13418
    UniProtKB/TrEMBL
    V9HWF0
    Conserved Domains (3) summary
    cd00204
    Location:28140
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:197449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
  4. XM_024448495.1XP_024304263.1  integrin-linked protein kinase isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:28140
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:228480
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
  5. XM_024448494.1XP_024304262.1  integrin-linked protein kinase isoform X1

    Related
    ENSP00000439606.2, ENST00000537806.5
    Conserved Domains (3) summary
    cd00204
    Location:28140
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:228480
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
  6. XM_024448498.1XP_024304266.1  integrin-linked protein kinase isoform X3

  7. XM_024448500.1XP_024304268.1  integrin-linked protein kinase isoform X4

    Conserved Domains (1) summary
    cd14057
    Location:94346
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
  8. XM_005252905.3XP_005252962.1  integrin-linked protein kinase isoform X5

    See identical proteins and their annotated locations for XP_005252962.1

    UniProtKB/Swiss-Prot
    Q13418
    Conserved Domains (1) summary
    cd14057
    Location:63315
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
  9. XM_024448496.1XP_024304264.1  integrin-linked protein kinase isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:28140
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:228480
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
  10. XM_011520065.1XP_011518367.1  integrin-linked protein kinase isoform X2

    See identical proteins and their annotated locations for XP_011518367.1

    UniProtKB/Swiss-Prot
    Q13418
    UniProtKB/TrEMBL
    V9HWF0
    Conserved Domains (3) summary
    cd00204
    Location:28140
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:197449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
  11. XM_024448497.1XP_024304265.1  integrin-linked protein kinase isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:28140
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:228480
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
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