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ILK integrin linked kinase [ Homo sapiens (human) ]

Gene ID: 3611, updated on 24-Nov-2020

Summary

Official Symbol
ILKprovided by HGNC
Official Full Name
integrin linked kinaseprovided by HGNC
Primary source
HGNC:HGNC:6040
See related
Ensembl:ENSG00000166333 MIM:602366
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P59; ILK-1; ILK-2; p59ILK; HEL-S-28
Summary
This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in endometrium (RPKM 90.1), prostate (RPKM 80.8) and 25 other tissues See more
Orthologs

Genomic context

See ILK in Genome Data Viewer
Location:
11p15.4
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (6603748..6610873)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6624938..6632105)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene voltage dependent anion channel 1 pseudogene Neighboring gene dynein heavy chain domain 1 Neighboring gene ribosomal RNA processing 8 Neighboring gene Sharpr-MPRA regulatory region 730 Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene tripeptidyl peptidase 1 Neighboring gene dachsous cadherin-related 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686F1765

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell aging IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
cell junction assembly TAS
Traceable Author Statement
more info
 
cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment or maintenance of epithelial cell apical/basal polarity IEA
Inferred from Electronic Annotation
more info
 
fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
myelin assembly IEA
Inferred from Electronic Annotation
more info
 
myelination in peripheral nervous system IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
nerve development IEA
Inferred from Electronic Annotation
more info
 
neuron projection morphogenesis IEA
Inferred from Electronic Annotation
more info
 
outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
platelet aggregation HMP PubMed 
positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
supramolecular fiber organization IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
costamere IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendritic shaft IEA
Inferred from Electronic Annotation
more info
 
focal adhesion HDA PubMed 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
sarcomere IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
integrin-linked protein kinase
Names
59 kDa serine/threonine-protein kinase
epididymis secretory protein Li 28
integrin-linked kinase-2
NP_001014794.1
NP_001014795.1
NP_001265370.1
NP_001265371.1
NP_004508.1
XP_005252961.1
XP_005252962.1
XP_011518367.1
XP_016873161.1
XP_024304262.1
XP_024304263.1
XP_024304264.1
XP_024304265.1
XP_024304266.1
XP_024304267.1
XP_024304268.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029702.1 RefSeqGene

    Range
    4975..12142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_444

mRNA and Protein(s)

  1. NM_001014794.3NP_001014794.1  integrin-linked protein kinase isoform 1

    See identical proteins and their annotated locations for NP_001014794.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    BC001554, DC380243, HY257434, U40282
    Consensus CDS
    CCDS7768.1
    UniProtKB/Swiss-Prot
    Q13418
    UniProtKB/TrEMBL
    V9HWF0
    Related
    ENSP00000403487.2, ENST00000420936.6
    Conserved Domains (4) summary
    cd14057
    Location:197449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:38124
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:454
    Ank_4; Ankyrin repeats (many copies)
  2. NM_001014795.3NP_001014795.1  integrin-linked protein kinase isoform 1

    See identical proteins and their annotated locations for NP_001014795.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AC091564, CR749220, DC379936, HY257434, U40282
    Consensus CDS
    CCDS7768.1
    UniProtKB/Swiss-Prot
    Q13418
    UniProtKB/TrEMBL
    V9HWF0
    Related
    ENSP00000379975.2, ENST00000396751.6
    Conserved Domains (4) summary
    cd14057
    Location:197449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:38124
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:454
    Ank_4; Ankyrin repeats (many copies)
  3. NM_001278441.2NP_001265370.1  integrin-linked protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001265370.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons in the coding region, which results in a section that contains a frameshift, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC091564, AK296628, DC380243, HY257434, U40282
    Consensus CDS
    CCDS60712.1
    UniProtKB/Swiss-Prot
    Q13418
    Related
    ENSP00000435323.1, ENST00000528995.5
    Conserved Domains (3) summary
    cd00204
    Location:28117
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:144388
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
  4. NM_001278442.2NP_001265371.1  integrin-linked protein kinase isoform 3

    See identical proteins and their annotated locations for NP_001265371.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, lacks an exon in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK293474
    Consensus CDS
    CCDS60713.1
    UniProtKB/Swiss-Prot
    Q13418
    Related
    ENSP00000434492.2, ENST00000532063.5
    Conserved Domains (1) summary
    cd14057
    Location:63315
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
  5. NM_004517.4NP_004508.1  integrin-linked protein kinase isoform 1

    See identical proteins and their annotated locations for NP_004508.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    DC380243, HY257434, U40282
    Consensus CDS
    CCDS7768.1
    UniProtKB/Swiss-Prot
    Q13418
    UniProtKB/TrEMBL
    V9HWF0
    Related
    ENSP00000299421.3, ENST00000299421.8
    Conserved Domains (4) summary
    cd14057
    Location:197449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:38124
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:454
    Ank_4; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    6603748..6610873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448499.1XP_024304267.1  integrin-linked protein kinase isoform X3

    Conserved Domains (3) summary
    cd14057
    Location:146398
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:1546
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:273
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_017017672.1XP_016873161.1  integrin-linked protein kinase isoform X3

    Conserved Domains (3) summary
    cd14057
    Location:146398
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:1546
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:273
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_005252904.5XP_005252961.1  integrin-linked protein kinase isoform X2

    See identical proteins and their annotated locations for XP_005252961.1

    UniProtKB/Swiss-Prot
    Q13418
    UniProtKB/TrEMBL
    V9HWF0
    Conserved Domains (4) summary
    cd14057
    Location:197449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:38124
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:454
    Ank_4; Ankyrin repeats (many copies)
  4. XM_024448495.1XP_024304263.1  integrin-linked protein kinase isoform X1

    Related
    ENST00000530016.5
    Conserved Domains (3) summary
    cd00204
    Location:28140
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:228480
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
  5. XM_024448494.1XP_024304262.1  integrin-linked protein kinase isoform X1

    Related
    ENSP00000439606.2, ENST00000537806.5
    Conserved Domains (3) summary
    cd00204
    Location:28140
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:228480
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
  6. XM_024448498.1XP_024304266.1  integrin-linked protein kinase isoform X3

    Conserved Domains (3) summary
    cd14057
    Location:146398
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:1546
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:273
    Ank_2; Ankyrin repeats (3 copies)
  7. XM_024448500.1XP_024304268.1  integrin-linked protein kinase isoform X4

    Conserved Domains (1) summary
    cd14057
    Location:94346
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
  8. XM_005252905.3XP_005252962.1  integrin-linked protein kinase isoform X5

    See identical proteins and their annotated locations for XP_005252962.1

    UniProtKB/Swiss-Prot
    Q13418
    Conserved Domains (1) summary
    cd14057
    Location:63315
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
  9. XM_024448496.1XP_024304264.1  integrin-linked protein kinase isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:28140
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:228480
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
  10. XM_011520065.1XP_011518367.1  integrin-linked protein kinase isoform X2

    See identical proteins and their annotated locations for XP_011518367.1

    UniProtKB/Swiss-Prot
    Q13418
    UniProtKB/TrEMBL
    V9HWF0
    Conserved Domains (4) summary
    cd14057
    Location:197449
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:38124
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:454
    Ank_4; Ankyrin repeats (many copies)
  11. XM_024448497.1XP_024304265.1  integrin-linked protein kinase isoform X1

    Conserved Domains (3) summary
    cd00204
    Location:28140
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14057
    Location:228480
    PK_ILK; Pseudokinase domain of Integrin Linked Kinase
    sd00045
    Location:3364
    ANK; ANK repeat [structural motif]
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