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Zdhhc12 zinc finger DHHC-type palmitoyltransferase 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366014, updated on 11-Apr-2024

Summary

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Official Symbol
Zdhhc12provided by RGD
Official Full Name
zinc finger DHHC-type palmitoyltransferase 12provided by RGD
Primary source
RGD:1306593
See related
Ensembl:ENSRNOG00000015791 AllianceGenome:RGD:1306593
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including gephyrin clustering involved in postsynaptic density assembly; peptidyl-L-cysteine S-palmitoylation; and positive regulation of GABAergic synaptic transmission. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC12 (zinc finger DHHC-type palmitoyltransferase 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 131.9), Kidney (RPKM 67.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zdhhc12 in Genome Data Viewer
Location:
3p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33761338..33764207, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13363504..13366383, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8656397..8659102, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene spectrin, alpha, non-erythrocytic 1 Neighboring gene dynein 2 intermediate chain 2 Neighboring gene Set nuclear proto-oncogene Neighboring gene protein kinase N3 Neighboring gene zyg-11 related, cell cycle regulator Neighboring gene TBC1 domain family, member 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. Ohno Y, et al. Mol Biol Cell, 2012 Dec. PMID 23034182, Free PMC Article
  2. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno Y, et al. Biochim Biophys Acta, 2006 Apr. PMID 16647879
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in gephyrin clustering involved in postsynaptic density assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in gephyrin clustering involved in postsynaptic density assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in gephyrin clustering involved in postsynaptic density assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of NLRP3 inflammasome complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NLRP3 inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synaptic transmission, GABAergic ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC12
Names
DHHC domain-containing cysteine-rich protein 12
DHHC-12
membrane-associated DHHC12 zinc finger protein
probable palmitoyltransferase ZDHHC12
zinc finger DHHC domain-containing protein 12
zinc finger, DHHC domain containing 12
zinc finger, DHHC-type containing 12
NP_001013257.1
XP_038961511.1
XP_038961512.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013239.1 → NP_001013257.1  palmitoyltransferase ZDHHC12

    See identical proteins and their annotated locations for NP_001013257.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076393
    UniProtKB/Swiss-Prot
    Q2TGJ7, Q6DGF5
    UniProtKB/TrEMBL
    A0A8L2QLS6, A6JTV1
    Related
    ENSRNOP00000039802.4, ENSRNOT00000050908.5
    Conserved Domains (1) summary
    pfam01529
    Location:123 → 217
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    33761338..33764207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105583.2 → XP_038961511.1  palmitoyltransferase ZDHHC12 isoform X1

    Conserved Domains (1) summary
    cl19890
    Location:156 → 168
    DHHC; DHHC palmitoyltransferase

  2. XM_039105584.2 → XP_038961512.1  palmitoyltransferase ZDHHC12 isoform X2

    UniProtKB/TrEMBL
    A6JTV2
    Conserved Domains (1) summary
    pfam01529
    Location:35 → 129
    DHHC; DHHC palmitoyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DGF5.1 GenPept UniProtKB/Swiss-Prot:Q6DGF5

Gene LinkOut

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