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ZDHHC12 zinc finger DHHC-type palmitoyltransferase 12 [ Homo sapiens (human) ]

Gene ID: 84885, updated on 1-Jun-2020

Summary

Official Symbol
ZDHHC12provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 12provided by HGNC
Primary source
HGNC:HGNC:19159
See related
Ensembl:ENSG00000160446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF400; DHHC-12
Expression
Ubiquitous expression in colon (RPKM 15.2), stomach (RPKM 13.4) and 25 other tissues See more
Orthologs

Genomic context

See ZDHHC12 in Genome Data Viewer
Location:
9q34.11
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128720869..128724138, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131483148..131486451, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376287 Neighboring gene SET nuclear proto-oncogene Neighboring gene RNA, 7SL, cytoplasmic 560, pseudogene Neighboring gene protein kinase N3 Neighboring gene uncharacterized LOC100506100 Neighboring gene zyg-11 related cell cycle regulator Neighboring gene CRISPRi-validated cis-regulatory element chr9.3033

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genetic variants associated with disordered eating.
NHGRI GWA Catalog
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14524, MGC13153, MGC54050

Gene Ontology Provided by GOA

Function Evidence Code Pubs
palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable palmitoyltransferase ZDHHC12
Names
zinc finger DHHC domain-containing protein 12
zinc finger DHHC-type containing 12
zinc finger protein 400
NP_001304944.2
NP_001304945.1
NP_001304949.2
NP_001304952.2
NP_116188.3
XP_011517418.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318015.2NP_001304944.2  probable palmitoyltransferase ZDHHC12 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL441992
  2. NM_001318016.2NP_001304945.1  probable palmitoyltransferase ZDHHC12 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in the 5' coding region and the 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL441992
    UniProtKB/Swiss-Prot
    Q96GR4
    Conserved Domains (1) summary
    cl19890
    Location:123162
    zf-DHHC; DHHC palmitoyltransferase
  3. NM_001318020.2NP_001304949.2  probable palmitoyltransferase ZDHHC12 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses alternate splice sites in the 5' coding region and the 3' terminal exon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL441992
  4. NM_001318023.2NP_001304952.2  probable palmitoyltransferase ZDHHC12 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses alternate in-frame splice sites in two exons compared to variant 1. It encodes isoform 4 which is shorter than isoform 1.
    Source sequence(s)
    AL441992
  5. NM_032799.5NP_116188.3  probable palmitoyltransferase ZDHHC12 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' coding region, compared to variant 1. It encodes isoform 5 which is shorter than isoform 1.
    Source sequence(s)
    AL441992
    Consensus CDS
    CCDS6909.1
    Related
    ENSP00000361748.4, ENST00000372663.9
    Conserved Domains (1) summary
    cl19890
    Location:123217
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    128720869..128724138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519116.2XP_011517418.1  probable palmitoyltransferase ZDHHC12 isoform X1

    Conserved Domains (1) summary
    cl19890
    Location:178220
    zf-DHHC; DHHC palmitoyltransferase
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