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Tubgcp4 tubulin gamma complex component 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362203, updated on 13-Apr-2024

Summary

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Official Symbol
Tubgcp4provided by RGD
Official Full Name
tubulin gamma complex component 4provided by RGD
Primary source
RGD:1306924
See related
Ensembl:ENSRNOG00000012798 AllianceGenome:RGD:1306924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306924
Summary
Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Predicted to be located in recycling endosome. Predicted to be part of gamma-tubulin complex. Predicted to be active in centrosome and equatorial microtubule organizing center. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 3. Orthologous to human TUBGCP4 (tubulin gamma complex associated protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 106.5), Brain (RPKM 99.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tubgcp4 in Genome Data Viewer
Location:
3q35
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128594052..128628789)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108141081..108172207)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113131292..113160750)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene adenosine deaminase-like Neighboring gene zinc finger and SCAN domain containing 29, pseudogene 1 Neighboring gene tumor protein p53 binding protein 1 Neighboring gene microtubule-associated protein 1A Neighboring gene diphosphoinositol pentakisphosphate kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rab11 endosomes contribute to mitotic spindle organization and orientation. Hehnly H, et al. Dev Cell, 2014 Mar 10. PMID 24561039, Free PMC Article
  2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in equatorial microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gamma-tubulin complex component 4
Names
tubulin, gamma complex associated protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399280.1 → NP_001386209.1  gamma-tubulin complex component 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HPM6
    Conserved Domains (2) summary
    pfam04130
    Location:350 → 655
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:2 → 347
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  2. NM_001399282.1 → NP_001386211.1  gamma-tubulin complex component 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6GK03
    Related
    ENSRNOP00000092022.1, ENSRNOT00000115059.1
    Conserved Domains (2) summary
    pfam04130
    Location:350 → 654
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:2 → 347
    GCP_N_terminal; Gamma tubulin complex component N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    128594052..128628789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106529.2 → XP_038962457.1  gamma-tubulin complex component 4 isoform X1

    UniProtKB/TrEMBL
    D3ZVR0
    Conserved Domains (2) summary
    pfam04130
    Location:339 → 644
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:2 → 336
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  2. XM_063284163.1 → XP_063140233.1  gamma-tubulin complex component 4 isoform X2

  3. XM_039106531.2 → XP_038962459.1  gamma-tubulin complex component 4 isoform X4

    Conserved Domains (2) summary
    pfam04130
    Location:350 → 474
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:2 → 347
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  4. XM_039106532.2 → XP_038962460.1  gamma-tubulin complex component 4 isoform X5

    Conserved Domains (1) summary
    pfam17681
    Location:2 → 286
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  5. XM_039106530.1 → XP_038962458.1  gamma-tubulin complex component 4 isoform X3

    Conserved Domains (2) summary
    pfam04130
    Location:214 → 519
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:2 → 211
    GCP_N_terminal; Gamma tubulin complex component N-terminal

RNA

  1. XR_010064663.1 RNA Sequence

  2. XR_005502399.2 RNA Sequence

  3. XR_001837217.3 RNA Sequence

  4. XR_010064664.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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