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TUBGCP4 tubulin gamma complex associated protein 4 [ Homo sapiens (human) ]

Gene ID: 27229, updated on 7-Jun-2020

Summary

Official Symbol
TUBGCP4provided by HGNC
Official Full Name
tubulin gamma complex associated protein 4provided by HGNC
Primary source
HGNC:HGNC:16691
See related
Ensembl:ENSG00000137822 MIM:609610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
76P; GCP4; GCP-4; Grip76; MCCRP3
Summary
This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Expression
Ubiquitous expression in brain (RPKM 7.5), thyroid (RPKM 5.7) and 25 other tissues See more
Orthologs

Genomic context

See TUBGCP4 in Genome Data Viewer
Location:
15q15.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (43371073..43409771)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43663257..43698258)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene adenosine deaminase like Neighboring gene zinc finger and SCAN domain containing 29 Neighboring gene RNA, 7SL, cytoplasmic 487, pseudogene Neighboring gene tumor protein p53 binding protein 1 Neighboring gene microtubule associated protein 1A Neighboring gene diphosphoinositol pentakisphosphate kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14797

Gene Ontology Provided by GOA

Function Evidence Code Pubs
gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule nucleation NAS
Non-traceable Author Statement
more info
PubMed 
microtubule nucleation by interphase microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
equatorial microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gamma-tubulin ring complex NAS
Non-traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
gamma-tubulin complex component 4
Names
gamma tubulin ring complex protein (76p gene)
gamma-ring complex protein 76 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042168.1 RefSeqGene

    Range
    5001..41037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001286414.3NP_001273343.1  gamma-tubulin complex component 4 isoform a

    See identical proteins and their annotated locations for NP_001273343.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC018924, AK027703, CK299820
    Consensus CDS
    CCDS66745.1
    UniProtKB/Swiss-Prot
    Q9UGJ1
    Related
    ENSP00000260383.7, ENST00000260383.11
    Conserved Domains (1) summary
    pfam04130
    Location:4573
    Spc97_Spc98; Spc97 / Spc98 family
  2. NM_014444.5NP_055259.2  gamma-tubulin complex component 4 isoform b

    See identical proteins and their annotated locations for NP_055259.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (b) is shorter than isoform 1.
    Source sequence(s)
    AC018924, BC012801, CK299820, DA396753
    Consensus CDS
    CCDS42030.1
    UniProtKB/Swiss-Prot
    Q9UGJ1
    Related
    ENSP00000456648.1, ENST00000564079.5
    Conserved Domains (1) summary
    pfam04130
    Location:4572
    Spc97_Spc98; Spc97 / Spc98 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    43371073..43409771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022078.2XP_016877567.1  gamma-tubulin complex component 4 isoform X2

  2. XM_011521454.3XP_011519756.1  gamma-tubulin complex component 4 isoform X1

    Conserved Domains (1) summary
    pfam04130
    Location:4573
    Spc97_Spc98; Spc97 / Spc98 family
  3. XM_011521455.2XP_011519757.1  gamma-tubulin complex component 4 isoform X3

    See identical proteins and their annotated locations for XP_011519757.1

    UniProtKB/Swiss-Prot
    Q9UGJ1
    Conserved Domains (1) summary
    pfam04130
    Location:1437
    Spc97_Spc98; Spc97 / Spc98 family

RNA

  1. XR_001751226.2 RNA Sequence

  2. XR_243092.4 RNA Sequence

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