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Cdadc1 cytidine and dCMP deaminase domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361052, updated on 6-Jun-2024

Summary

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Official Symbol
Cdadc1provided by RGD
Official Full Name
cytidine and dCMP deaminase domain containing 1provided by RGD
Primary source
RGD:1311845
See related
Ensembl:ENSRNOG00000012209 AllianceGenome:RGD:1311845
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including cytidine deaminase activity; importin-alpha family protein binding activity; and protein homodimerization activity. Predicted to be involved in DNA cytosine deamination and cytidine deamination. Predicted to be located in cytoplasm and nucleus. Orthologous to human CDADC1 (cytidine and dCMP deaminase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 314.9), Heart (RPKM 203.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdadc1 in Genome Data Viewer
Location:
15p12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (37902789..37934853, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (33726590..33755611, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (39865094..39894122, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene SET domain bifurcated histone lysine methyltransferase 2 Neighboring gene calcium binding protein 39-like Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC120097001 Neighboring gene uncharacterized LOC134481975 Neighboring gene ribosomal protein S9, pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural and biological function of NYD-SP15 as a new member of cytidine deaminases. Xu Y, et al. Gene, 2016 May 25. PMID 26945630
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytidine deaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables importin-alpha family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA cytosine deamination ISO
Inferred from Sequence Orthology
more info
  
involved_in cytidine deamination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytidine and dCMP deaminase domain-containing protein 1
NP_001012156.1
NP_001386504.1
NP_001386505.1
XP_006252188.1
XP_008768982.1
XP_038949430.1
XP_063130483.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012156.2 → NP_001012156.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001012156.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6K685, F1MAC1, Q5XIE7
    Conserved Domains (1) summary
    cl00269
    Location:75 → 152
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

  2. NM_001399575.1 → NP_001386504.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A8I6A0N0, A0A8I6A301, A6K681
    Related
    ENSRNOP00000085311.1, ENSRNOT00000104311.1

  3. NM_001399576.1 → NP_001386505.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A0G2KAJ9, A0A8I6AFB7, A6K683
    Related
    ENSRNOP00000090984.1, ENSRNOT00000115313.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    37902789..37934853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008770760.4 → XP_008768982.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A0N0, A0A8I6A8W1, A6K681
    Related
    ENSRNOP00000087904.1
    Conserved Domains (2) summary
    cd01286
    Location:295 → 430
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    cl00269
    Location:58 → 127
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

  2. XM_006252126.5 → XP_006252188.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A6K682
    Conserved Domains (2) summary
    cd01286
    Location:224 → 359
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    cl00269
    Location:13 → 56
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

  3. XM_039093502.2 → XP_038949430.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2KAJ9
    Conserved Domains (2) summary
    cd01286
    Location:320 → 455
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    cl00269
    Location:75 → 152
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

  4. XM_063274413.1 → XP_063130483.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2KAJ9
Nucleotide Protein Strain
Heading Accession and Version

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