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CDADC1 cytidine and dCMP deaminase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 81602, updated on 21-Dec-2019

Summary

Official Symbol
CDADC1provided by HGNC
Official Full Name
cytidine and dCMP deaminase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:20299
See related
Ensembl:ENSG00000102543
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NYD-SP15; bA103J18.1
Expression
Broad expression in thyroid (RPKM 5.8), testis (RPKM 5.7) and 24 other tissues See more
Orthologs

Genomic context

See CDADC1 in Genome Data Viewer
Location:
13q14.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (49247875..49293486)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (49822047..49867622)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370203 Neighboring gene THAP domain containing 12 pseudogene 10 Neighboring gene Sharpr-MPRA regulatory region 13963 Neighboring gene calcium binding protein 39 like Neighboring gene SETDB2-PHF11 readthrough Neighboring gene SET domain bifurcated histone lysine methyltransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC41774, MGC57136, MGC150615

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytidine deaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
dCMP deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
importin-alpha family protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
DNA cytosine deamination IDA
Inferred from Direct Assay
more info
PubMed 
cytidine deamination IDA
Inferred from Direct Assay
more info
PubMed 
dTMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dUMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
cytidine and dCMP deaminase domain-containing protein 1
Names
protein kinase NYD-SP15
testis development protein NYD-SP15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193478.2NP_001180407.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the last splice junction compared to variant 1. The resulting isoform (2) is shorter than isoform 1 at the C-terminus.
    Source sequence(s)
    BC048092, BC125203, DA400049
    UniProtKB/Swiss-Prot
    Q9BWV3
    Conserved Domains (2) summary
    cd01286
    Location:319454
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    cl00269
    Location:79151
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
  2. NM_030911.4NP_112173.1  cytidine and dCMP deaminase domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_112173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC048092, BC125202, DA400049
    Consensus CDS
    CCDS9415.1
    UniProtKB/Swiss-Prot
    Q9BWV3
    Related
    ENSP00000251108.6, ENST00000251108.10
    Conserved Domains (2) summary
    cd01286
    Location:319454
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    cl00269
    Location:79151
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

RNA

  1. NR_036439.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the CDS, resulting in a premature stop codon, compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate and does not encode a functional protein.
    Source sequence(s)
    AK297400, BC048092, BC125202, DA400049

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    49247875..49293486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535253.1XP_011533555.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011533555.1

    Conserved Domains (2) summary
    cd01286
    Location:201336
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    cl00269
    Location:1533
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
  2. XM_024449420.1XP_024305188.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X4

    Conserved Domains (1) summary
    cd01286
    Location:180315
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  3. XM_017020780.1XP_016876269.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X5

    Conserved Domains (1) summary
    cd01286
    Location:121256
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  4. XM_017020783.1XP_016876272.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X5

    Conserved Domains (1) summary
    cd01286
    Location:121256
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  5. XM_017020779.1XP_016876268.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X5

    Conserved Domains (1) summary
    cd01286
    Location:121256
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  6. XM_024449421.1XP_024305189.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X5

    Conserved Domains (1) summary
    cd01286
    Location:121256
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  7. XM_017020781.2XP_016876270.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X5

    Conserved Domains (1) summary
    cd01286
    Location:121256
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  8. XM_011535251.1XP_011533553.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011533553.1

    Conserved Domains (2) summary
    cd01286
    Location:274409
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    cl00269
    Location:34106
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
  9. XM_011535250.2XP_011533552.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd01286
    Location:333468
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
    cl00269
    Location:93165
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
  10. XM_017020782.1XP_016876271.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X5

    Conserved Domains (1) summary
    cd01286
    Location:121256
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  11. XM_017020778.1XP_016876267.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X4

    Conserved Domains (1) summary
    cd01286
    Location:180315
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  12. XM_017020784.1XP_016876273.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X5

    Conserved Domains (1) summary
    cd01286
    Location:121256
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  13. XM_006719871.3XP_006719934.1  cytidine and dCMP deaminase domain-containing protein 1 isoform X4

    Conserved Domains (1) summary
    cd01286
    Location:180315
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
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