U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ten1 TEN1 subunit of CST complex [ Rattus norvegicus (Norway rat) ]

Gene ID: 360664, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Ten1provided by RGD
Official Full Name
TEN1 subunit of CST complexprovided by RGD
Primary source
RGD:1311078
See related
EnsemblRapid:ENSRNOG00000060307 AllianceGenome:RGD:1311078
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311078
Summary
Predicted to enable telomerase inhibitor activity and telomeric DNA binding activity. Predicted to be involved in negative regulation of telomere maintenance via telomerase. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of CST complex. Orthologous to human TEN1 (TEN1 subunit of CST complex). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 55.0), Lung (RPKM 53.4) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10q32.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101930212..101951932)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101431328..101455105)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105073077..105095094)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Fas binding factor 1 Neighboring gene small Cajal body-specific RNA 4 Neighboring gene acyl-CoA oxidase 1 Neighboring gene uncharacterized LOC134480905 Neighboring gene envoplakin Neighboring gene uncharacterized LOC120095213 Neighboring gene signal recognition particle 68

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The human CST complex is a terminator of telomerase activity. Chen LY, et al. Nature, 2012 Aug 23. PMID 22763445
  2. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Miyake Y, et al. Mol Cell, 2009 Oct 23. PMID 19854130
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables telomerase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of telomere maintenance via telomerase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CST complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CST complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
CST complex subunit TEN1
Names
TEN1 CST complex subunit
TEN1 telomerase capping complex subunit

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108307.1 → NP_001101777.1  CST complex subunit TEN1

    See identical proteins and their annotated locations for NP_001101777.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A0A0G2K213, A6HKU9
    Related
    ENSRNOP00000109729.1, ENSRNOT00000155381.1
    Conserved Domains (1) summary
    pfam15490
    Location:2 → 118
    Ten1_2; Telomere-capping, CST complex subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    101930212..101951932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086432.2 → XP_038942360.1  CST complex subunit TEN1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K213, A6HKU9
    Conserved Domains (1) summary
    pfam15490
    Location:2 → 118
    Ten1_2; Telomere-capping, CST complex subunit

  2. XM_039086431.2 → XP_038942359.1  CST complex subunit TEN1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K213, A6HKU9
    Conserved Domains (1) summary
    pfam15490
    Location:2 → 118
    Ten1_2; Telomere-capping, CST complex subunit
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous