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EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 [ Bos taurus (cattle) ]

Gene ID: 347700, updated on 5-Mar-2024

Summary

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Official Symbol
EIF2AK2provided by VGNC
Official Full Name
eukaryotic translation initiation factor 2 alpha kinase 2provided by VGNC
Primary source
VGNC:VGNC:28381
See related
BGD:BT26027; Ensembl:ENSBTAG00000008703
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
PKR; PRKR
Orthologs
human mouse all
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Genomic context

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See EIF2AK2 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (19556767..19597286, complement)

Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene striatin Neighboring gene HEAT repeat containing 5B Neighboring gene G-patch domain containing 11 Neighboring gene uncharacterized LOC112448863 Neighboring gene CEBPZ opposite strand Neighboring gene CCAAT enhancer binding protein zeta Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7 Neighboring gene protein kinase D3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Modulation of PKR activity in cells infected by bovine viral diarrhea virus. Gil LH, et al. Virus Res, 2006 Mar. PMID 16194578
  2. The mRNA regulation of porcine double-stranded RNA-activated protein kinase gene. Asano A, et al. J Vet Med Sci, 2004 Dec. PMID 15644602
  3. Tumour necrosis factor alpha up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-alpha in articular chondrocytes. Gilbert SJ, et al. Biochem Soc Trans, 2002 Nov. PMID 12440939
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Infection with cp BVDV was found to induce PKR activation.
    Title: Modulation of PKR activity in cells infected by bovine viral diarrhea virus.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interferon-induced, double-stranded RNA-activated protein kinase
Names
protein kinase, interferon-inducible double stranded RNA dependent
NP_835210.2
XP_005212626.1
XP_005212627.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178109.3 → NP_835210.2  interferon-induced, double-stranded RNA-activated protein kinase

    See identical proteins and their annotated locations for NP_835210.2

    Status: PROVISIONAL

    Source sequence(s)
    BC126646
    UniProtKB/TrEMBL
    A0JNE6, Q865A3
    Related
    ENSBTAP00000011469.4, ENSBTAT00000011469.5
    Conserved Domains (3) summary
    smart00358
    Location:101 → 166
    DSRM; Double-stranded RNA binding motif
    pfam00069
    Location:263 → 516
    Pkinase; Protein kinase domain
    cl21453
    Location:256 → 518
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    19556767..19597286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005212570.5 → XP_005212627.1  interferon-induced, double-stranded RNA-activated protein kinase isoform X2

    UniProtKB/TrEMBL
    Q865A3
    Conserved Domains (3) summary
    smart00358
    Location:101 → 166
    DSRM; Double-stranded RNA binding motif
    pfam00069
    Location:262 → 515
    Pkinase; Protein kinase domain
    cl21453
    Location:255 → 517
    PKc_like; Protein Kinases, catalytic domain

  2. XM_005212569.5 → XP_005212626.1  interferon-induced, double-stranded RNA-activated protein kinase isoform X1

    See identical proteins and their annotated locations for XP_005212626.1

    UniProtKB/TrEMBL
    A0JNE6, Q865A3
    Conserved Domains (3) summary
    smart00358
    Location:101 → 166
    DSRM; Double-stranded RNA binding motif
    pfam00069
    Location:263 → 516
    Pkinase; Protein kinase domain
    cl21453
    Location:256 → 518
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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