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grm2a glutamate receptor, metabotropic 2a [ Danio rerio (zebrafish) ]

Gene ID: 336153, updated on 12-Sep-2024

Summary

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Official Symbol
grm2aprovided by ZNC
Official Full Name
glutamate receptor, metabotropic 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8097
See related
Ensembl:ENSDARG00000004150 AllianceGenome:ZFIN:ZDB-GENE-030131-8097
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fj52c07
Summary
Predicted to enable group II metabotropic glutamate receptor activity. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in brain; retinal neural layer; and trigeminal ganglion. Orthologous to human GRM2 (glutamate metabotropic receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (42051514..42141177, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (42053973..42143647, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 61-like Neighboring gene poly (ADP-ribose) polymerase family, member 3 Neighboring gene testis expressed 264, ER-phagy receptor a Neighboring gene FA complementation group D2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Phylogeny and expression divergence of metabotropic glutamate receptor genes in the brain of zebrafish (Danio rerio). Haug MF, et al. J Comp Neurol, 2013 May 1. PMID 23047810
  2. Novel expression patterns of metabotropic glutamate receptor 6 in the zebrafish nervous system. Huang YY, et al. PLoS One, 2012. PMID 22523578, Free PMC Article
  3. Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. Coppola U, et al. BMC Evol Biol, 2016 Jan 27. PMID 26818140, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables group II metabotropic glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
metabotropic glutamate receptor 2
Names
metabotropic glutamate receptor 2a
mglur2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302225.1 → NP_001289154.1  metabotropic glutamate receptor 2 precursor

    See identical proteins and their annotated locations for NP_001289154.1

    Status: PROVISIONAL

    Source sequence(s)
    KF234083
    UniProtKB/TrEMBL
    U3N5X6
    Related
    ENSDARP00000152371.1, ENSDART00000181772.1
    Conserved Domains (4) summary
    cd06375
    Location:51 → 501
    PBP1_mGluR_groupII; Ligand binding domain of the group II metabotropic glutamate receptor
    pfam00003
    Location:595 → 832
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:81 → 476
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:513 → 561
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    42051514..42141177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476790.2 → XP_021332465.1  metabotropic glutamate receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BDP3, E7FDL9
    Conserved Domains (4) summary
    cd06375
    Location:58 → 508
    PBP1_mGluR_groupII; Ligand binding domain of the group II metabotropic glutamate receptor
    pfam07562
    Location:520 → 569
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd14964
    Location:590 → 614
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:589 → 842
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_005166117.5 → XP_005166174.1  metabotropic glutamate receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BDP3, E7FDL9
    Conserved Domains (4) summary
    cd06375
    Location:58 → 508
    PBP1_mGluR_groupII; Ligand binding domain of the group II metabotropic glutamate receptor
    pfam07562
    Location:520 → 569
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd14964
    Location:590 → 614
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:589 → 842
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version

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