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CG41099 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355072, updated on 10-May-2024

Summary

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Official Symbol
CG41099provided by FlyBase
Primary source
FLYBASE:FBgn0039955
Locus tag
Dmel_CG41099
See related
AllianceGenome:FB:FBgn0039955
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:GM10035; CG17416; CG17419; Dmel\CG41099; FBgn0039955; GM10035; Rabankyrin
Summary
Predicted to enable metal ion binding activity. Involved in embryonic morphogenesis; endocytosis; and epithelial cell morphogenesis. Located in vacuole. Is expressed in adult head; head mesoderm; organism; trunk mesoderm; and ventral ectoderm. Orthologous to human ANKFY1 (ankyrin repeat and FYVE domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG41099 in Genome Data Viewer
Location:
81F5-81F5; 3-47.1 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (3846729..3868401)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3RHet NW_001848858.1 (1684395..1706067, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Translocase of the inner mitochondrial membrane 17b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutamine:fructose-6-phosphate aminotransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NMFP: a non-negative matrix factorization based preselection method to increase accuracy of identifying mRNA isoforms from RNA-seq data. Ye Y, et al. BMC Genomics, 2016 Jan 11. PMID 26818007, Free PMC Article
  2. Tubular endocytosis drives remodelling of the apical surface during epithelial morphogenesis in Drosophila. Fabrowski P, et al. Nat Commun, 2013. PMID 23921440, Free PMC Article
  3. Vav independently regulates synaptic growth and plasticity through distinct actin-based processes. Park HG, et al. J Cell Biol, 2022 Oct 3. PMID 35976098, Free PMC Article
  4. Predicting host dependency factors of pathogens in Drosophila melanogaster using machine learning. Aromolaran O, et al. Comput Struct Biotechnol J, 2021. PMID 34471501, Free PMC Article
  5. BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis. Kim N, et al. Nat Commun, 2019 Feb 8. PMID 30737382, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryonic morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vacuole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG41099-PB
CG41099-PC
CG41099-PD
CG41099-PE
D-Rabankyrin
Rabankyrin-5
rabankyrin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    3846729..3868401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001110981.2 → NP_001104451.1  uncharacterized protein Dmel_CG41099, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001104451.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8Y582
    Conserved Domains (7) summary
    smart00225
    Location:73 → 164
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG0666
    Location:750 → 975
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:818 → 942
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd15728
    Location:1052 → 1114
    FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
    pfam00651
    Location:65 → 162
    BTB; BTB/POZ domain
    pfam12796
    Location:577 → 668
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:820 → 853
    ANK; ANK repeat [structural motif]

  2. NM_001110980.2 → NP_001104450.2  uncharacterized protein Dmel_CG41099, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001104450.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8Y583, Q7PLP4
    Conserved Domains (7) summary
    smart00225
    Location:62 → 153
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG0666
    Location:739 → 964
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:807 → 931
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd15728
    Location:1041 → 1103
    FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
    pfam00651
    Location:54 → 151
    BTB; BTB/POZ domain
    pfam12796
    Location:566 → 657
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:809 → 842
    ANK; ANK repeat [structural motif]

  3. NM_001015360.3 → NP_001015360.1  uncharacterized protein Dmel_CG41099, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015360.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8Y583, Q7PLP4
    Conserved Domains (7) summary
    smart00225
    Location:62 → 153
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG0666
    Location:739 → 964
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:807 → 931
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd15728
    Location:1041 → 1103
    FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
    pfam00651
    Location:54 → 151
    BTB; BTB/POZ domain
    pfam12796
    Location:566 → 657
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:809 → 842
    ANK; ANK repeat [structural motif]

  4. NM_001015359.3 → NP_001015359.1  uncharacterized protein Dmel_CG41099, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001015359.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7PLP5
    Conserved Domains (7) summary
    smart00225
    Location:75 → 166
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG0666
    Location:752 → 977
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:820 → 944
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd15728
    Location:1054 → 1116
    FYVE_ANFY1; FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins
    pfam00651
    Location:67 → 164
    BTB; BTB/POZ domain
    pfam12796
    Location:579 → 670
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:822 → 855
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8Y582 A8Y582
Q5BI36 Q5BI36
Q7PLP4 Q7PLP4
Q7PLP5 Q7PLP5
Q8SY24 Q8SY24

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