larp6a La ribonucleoprotein 6, translational regulator a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: larp6aprovided by ZNC
Official Full Name: La ribonucleoprotein 6, translational regulator aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6403
See related: Ensembl:ENSDARG00000005355 AllianceGenome:ZFIN:ZDB-GENE-030131-6403
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: larp6; fi75f12; zgc:66107; wu:fi75f12
Summary: Enables RNA binding activity. Acts upstream of or within somitogenesis. Predicted to be part of polysome. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; mesenchymal cell; post-vent region; segmental plate; and trunk. Orthologous to human LARP6 (La ribonucleoprotein 6, translational regulator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (173603..194844)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (284467..305708)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Larp6 proteins are required for normal oocyte development, chorion formation and egg activation
Title: Maternal Larp6 controls oocyte development, chorion formation and elevation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: la-related protein 6a

Names: La ribonucleoprotein domain family, member 6; La ribonucleoprotein domain family, member 6a; ZFOS-508H5.1; acheron; achn

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199903.1 → NP_956197.1 la-related protein 6a

See identical proteins and their annotated locations for NP_956197.1

Status: PROVISIONAL

Source sequence(s)

BC056595

UniProtKB/TrEMBL

A0A8M1PDN5, Q6PHD4

Related

ENSDARP00000153929.1, ENSDART00000185918.1

Conserved Domains (3) summary

cd08033
Location:79 → 155

LARP_6; La RNA-binding domain of La-related protein 6

cd12289
Location:200 → 284

RRM_LARP6; RNA recognition motif in La-related protein 6 (LARP6) and similar proteins

pfam12901
Location:457 → 472

SUZ-C; SUZ-C motif