kpna4 karyopherin alpha 4 (importin alpha 3) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kpna4provided by ZNC
Official Full Name: karyopherin alpha 4 (importin alpha 3)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5584
See related: Ensembl:ENSDARG00000023190 AllianceGenome:ZFIN:ZDB-GENE-030131-5584
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: impa3; wu:fa56d07; wu:fa66g10; wu:fe14c04; wu:fi04h11; wu:fi19b05
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of or within protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Orthologous to human KPNA4 (karyopherin subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 15

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (1596508..1622454, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (1631599..1657545, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

fa66g10.s1 (e-PCR)
- UniSTS:202546

AA658753 (e-PCR)
- UniSTS:205386

fb80e06.x1 (e-PCR)
- UniSTS:191562

fa56d07 (e-PCR)
- UniSTS:188823

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lens development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: importin subunit alpha-3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201305.1 → NP_958462.1 importin subunit alpha-3

See identical proteins and their annotated locations for NP_958462.1

Status: PROVISIONAL

Source sequence(s)

BC045358

UniProtKB/TrEMBL

Q7ZVY9

Related

ENSDARP00000039386.8, ENSDART00000034456.10

Conserved Domains (4) summary

COG5064
Location:2 → 520

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

cd00020
Location:108 → 229

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam01749
Location:10 → 93

IBB; Importin beta binding domain

sd00043
Location:109 → 142

ARM; armadillo repeat [structural motif]