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Kpna4 karyopherin (importin) alpha 4 [ Mus musculus (house mouse) ]

Gene ID: 16649, updated on 8-Dec-2022

Summary

Official Symbol
Kpna4provided by MGI
Official Full Name
karyopherin (importin) alpha 4provided by MGI
Primary source
MGI:MGI:1100848
See related
Ensembl:ENSMUSG00000027782 AllianceGenome:MGI:1100848
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
qip1; IPOA3; 1110058D08Rik
Summary
Enables nuclear import signal receptor activity. Acts upstream of or within protein import into nucleus and response to hydrogen peroxide. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human KPNA4 (karyopherin subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 14.2), CNS E11.5 (RPKM 14.0) and 28 other tissues See more
Orthologs
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Genomic context

See Kpna4 in Genome Data Viewer
Location:
3; 3 E1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (68979554..69034425, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (69072221..69127092, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 59 Neighboring gene RIKEN cDNA 9630025H16 gene Neighboring gene predicted gene, 22009 Neighboring gene predicted gene 1647 Neighboring gene predicted gene, 54203

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear import signal receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of NLS-dependent protein nuclear import complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
importin subunit alpha-3
Names
importin alpha 3
importin alpha Q1
importin subunit alpha-4
karyopherin subunit alpha-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008467.4NP_032493.1  importin subunit alpha-3

    See identical proteins and their annotated locations for NP_032493.1

    Status: PROVISIONAL

    Source sequence(s)
    AC119847
    Consensus CDS
    CCDS17403.1
    UniProtKB/Swiss-Prot
    O35343
    UniProtKB/TrEMBL
    Q4FJX1
    Related
    ENSMUSP00000141227.2, ENSMUST00000194558.6
    Conserved Domains (2) summary
    COG5064
    Location:11513
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:279311
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    68979554..69034425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)