U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

fkbp4 FKBP prolyl isomerase 4 [ Danio rerio (zebrafish) ]

Gene ID: 321795, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
fkbp4provided by ZNC
Official Full Name
FKBP prolyl isomerase 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-514
See related
Ensembl:ENSDARG00000008447 AllianceGenome:ZFIN:ZDB-GENE-030131-514
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb34f09
Summary
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding and protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm. Orthologous to human FKBP4 (FKBP prolyl isomerase 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See fkbp4 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (6536284..6550504)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (6395922..6410013)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene WAS protein family homolog 1 Neighboring gene DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 3b Neighboring gene troponin I, skeletal, slow c

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Functional Comparison of Human and Zebra Fish FKBP52 Confirms the Importance of the Proline-Rich Loop for Regulation of Steroid Hormone Receptor Activity. Harris DC, et al. Int J Mol Sci, 2019 Oct 28. PMID 31661769, Free PMC Article
  2. Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy. Giustiniani J, et al. Proc Natl Acad Sci U S A, 2014 Mar 25. PMID 24623856, Free PMC Article
  3. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT acts_upstream_of_or_within regulation of androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP4
Names
FK506 binding protein 4
FKBP52
NP_958877.1
XP_005173673.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201469.1 → NP_958877.1  peptidyl-prolyl cis-trans isomerase FKBP4

    See identical proteins and their annotated locations for NP_958877.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045387
    UniProtKB/TrEMBL
    Q7ZVW2
    Related
    ENSDARP00000013076.7, ENSDART00000024576.9
    Conserved Domains (6) summary
    TIGR03516
    Location:153 → 249
    ppisom_GldI; peptidyl-prolyl isomerase, gliding motility-associated
    sd00006
    Location:269 → 293
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:38 → 129
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam00515
    Location:316 → 347
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:316 → 379
    TPR_11; TPR repeat
    pfam13432
    Location:270 → 348
    TPR_16; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    6536284..6550504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173616.4 → XP_005173673.1  peptidyl-prolyl cis-trans isomerase FKBP4 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BKV5, F8W2D1
    Related
    ENSDARP00000124772.1, ENSDART00000149350.2
    Conserved Domains (6) summary
    TIGR03516
    Location:153 → 249
    ppisom_GldI; peptidyl-prolyl isomerase, gliding motility-associated
    sd00006
    Location:269 → 293
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:38 → 129
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam00515
    Location:316 → 347
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:316 → 379
    TPR_11; TPR repeat
    pfam13432
    Location:270 → 348
    TPR_16; Tetratricopeptide repeat
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous