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Fkbp4 FK506 binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 14228, updated on 5-Jan-2023

Summary

Official Symbol
Fkbp4provided by MGI
Official Full Name
FK506 binding protein 4provided by MGI
Primary source
MGI:MGI:95543
See related
Ensembl:ENSMUSG00000030357 AllianceGenome:MGI:95543
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p59; FKBP-4; FKBP52; FKPB52; FKBP-52
Summary
Enables several functions, including glucocorticoid receptor binding activity; heat shock protein binding activity; and purine ribonucleoside triphosphate binding activity. Acts upstream of or within several processes, including androgen receptor signaling pathway; embryo implantation; and steroid hormone receptor complex assembly. Located in nucleus. Is expressed in pancreas epithelium. Used to study androgen insensitivity syndrome. Orthologous to human FKBP4 (FKBP prolyl isomerase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 152.7), testis adult (RPKM 150.6) and 28 other tissues See more
Orthologs
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Genomic context

See Fkbp4 in Genome Data Viewer
Location:
6; 6 F3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128407066..128415619, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128430103..128438656, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene forkhead box M1 Neighboring gene testis expressed 52 Neighboring gene nuclear receptor interacting protein 2 Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene predicted gene 10069 Neighboring gene STAM binding protein, pseudogene 1 Neighboring gene peptidyl prolyl isomerase H pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables FK506 binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables copper-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclear glucocorticoid receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tau protein binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP4
Names
52 kDa FK506-binding protein
52 kDa FKBP
59 kDa immunophilin
FKBP59
HBI
HSP-binding immunophilin
PPIase FKBP4
immunophilin FKBP52
rotamase
NP_034349.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010219.4NP_034349.1  peptidyl-prolyl cis-trans isomerase FKBP4

    See identical proteins and their annotated locations for NP_034349.1

    Status: VALIDATED

    Source sequence(s)
    AK083912, BY280598, X17069
    Consensus CDS
    CCDS20573.1
    UniProtKB/Swiss-Prot
    P30416, Q3TVC9
    Related
    ENSMUSP00000032508.5, ENSMUST00000032508.11
    Conserved Domains (4) summary
    sd00006
    Location:274301
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:43134
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam00515
    Location:321352
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:322384
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    128407066..128415619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)