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Ankrd23 ankyrin repeat domain 23 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316330, updated on 30-Mar-2024

Summary

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Official Symbol
Ankrd23provided by RGD
Official Full Name
ankyrin repeat domain 23provided by RGD
Primary source
RGD:1310398
See related
Ensembl:ENSRNOG00000016151 AllianceGenome:RGD:1310398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable titin binding activity. Involved in response to mechanical stimulus. Located in intercalated disc; myofibril; and nucleus. Biomarker of type 2 diabetes mellitus. Orthologous to human ANKRD23 (ankyrin repeat domain 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 4017.6) See more
Orthologs
human mouse all
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Genomic context

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Location:
9q21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (46269107..46274578, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (38773234..38778705, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (43110980..43117585, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 4 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 3 Neighboring gene ankyrin repeat domain 39 Neighboring gene semaphorin 4C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Vascular cell transcriptomic changes to exercise training differ directionally along and between skeletal muscle arteriolar trees. Laughlin MH, et al. Microcirculation, 2017 Feb. PMID 27889934
  2. Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Nagueh SF, et al. Circulation, 2004 Jul 13. PMID 15238456
  3. Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals. Ikeda K, et al. J Biol Chem, 2003 Feb 7. PMID 12456686
  4. Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Barash IA, et al. Am J Physiol Cell Physiol, 2007 Jul. PMID 17392382
  5. The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules. Miller MK, et al. J Mol Biol, 2003 Nov 7. PMID 14583192

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables titin binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of sarcomere organization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to muscle stretch ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in I band ISO
Inferred from Sequence Orthology
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercalated disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myofibril IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108211.2 → NP_001101681.1  ankyrin repeat domain-containing protein 23

    See identical proteins and their annotated locations for NP_001101681.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6B0D0, A0A8I6GH25, A6IND8
    Related
    ENSRNOP00000094368.1, ENSRNOT00000113028.1
    Conserved Domains (3) summary
    sd00045
    Location:179 → 208
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:118 → 165
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:149 → 241
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    46269107..46274578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083570.2 → XP_038939498.1  ankyrin repeat domain-containing protein 23 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GH25, D3ZVB9
    Related
    ENSRNOP00000032505.5
    Conserved Domains (3) summary
    sd00045
    Location:171 → 200
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:110 → 157
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:141 → 233
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_039083571.2 → XP_038939499.1  ankyrin repeat domain-containing protein 23 isoform X2

    Conserved Domains (2) summary
    sd00045
    Location:151 → 182
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:126 → 182
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version

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