Format

Send to:

Choose Destination

ANKRD23 ankyrin repeat domain 23 [ Homo sapiens (human) ]

Gene ID: 200539, updated on 11-Jun-2021

Summary

Official Symbol
ANKRD23provided by HGNC
Official Full Name
ankyrin repeat domain 23provided by HGNC
Primary source
HGNC:HGNC:24470
See related
Ensembl:ENSG00000163126 MIM:610736
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DARP; MARP3
Summary
This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like repeats. The protein is localized to the nucleus, functioning as a transcriptional regulator. Expression of this protein is induced during recovery following starvation. [provided by RefSeq, Jul 2008]
Expression
Broad expression in prostate (RPKM 8.9), esophagus (RPKM 4.7) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ANKRD23 in Genome Data Viewer
Location:
2q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (96837912..96844021, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (97503649..97509758, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CNNM3 divergent transcript Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 3 Neighboring gene ankyrin repeat domain 39 Neighboring gene semaphorin 4C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32449, MGC129593

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables titin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intercalated disc IEA
Inferred from Electronic Annotation
more info
 
located_in myofibril IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ankyrin repeat domain-containing protein 23
Names
diabetes related ankyrin repeat protein
muscle ankyrin repeat protein 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144994.8NP_659431.5  ankyrin repeat domain-containing protein 23

    See identical proteins and their annotated locations for NP_659431.5

    Status: REVIEWED

    Source sequence(s)
    AC092636, AK092564, AY196212, BC107056, BF827606
    Consensus CDS
    CCDS2027.1
    UniProtKB/Swiss-Prot
    Q86SG2
    Related
    ENSP00000321679.4, ENST00000318357.9
    Conserved Domains (3) summary
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:178207
    ANK; ANK repeat [structural motif]
    cl27857
    Location:225303
    PHA02917; ankyrin-like protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    96837912..96844021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center