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Asb8 ankyrin repeat and SOCS box-containing 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315287, updated on 18-Sep-2024

Summary

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Official Symbol
Asb8provided by RGD
Official Full Name
ankyrin repeat and SOCS box-containing 8provided by RGD
Primary source
RGD:1309246
See related
EnsemblRapid:ENSRNOG00000075267 AllianceGenome:RGD:1309246
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB8 (ankyrin repeat and SOCS box containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 349.3), Heart (RPKM 258.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q36
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131140455..131176648, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (129261397..129297492, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (139724337..139760410, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene phosphofructokinase, muscle Neighboring gene uncharacterized LOC134479569 Neighboring gene transfer RNA threonine (anticodon AGU) 34 Neighboring gene uncharacterized LOC120093732 Neighboring gene coiled-coil domain containing 184 Neighboring gene olfactory receptor family 10 subfamily AD member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 8
Names
ankyrin repeat and SOCS box-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108109.2 → NP_001101579.1  ankyrin repeat and SOCS box protein 8

    See identical proteins and their annotated locations for NP_001101579.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168888
    UniProtKB/TrEMBL
    A0A0G2JWD3, B5DF17, F7F2V9
    Conserved Domains (3) summary
    PHA02876
    Location:26 → 215
    PHA02876; ankyrin repeat protein; Provisional
    cd03727
    Location:245 → 287
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:56 → 83
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    131140455..131176648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594889.3 → XP_017450378.3  ankyrin repeat and SOCS box protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWD3

  2. XM_006242328.4 → XP_006242390.1  ankyrin repeat and SOCS box protein 8 isoform X2

    See identical proteins and their annotated locations for XP_006242390.1

    UniProtKB/TrEMBL
    A0A0G2JWD3, B5DF17, F7F2V9
    Related
    ENSRNOP00000102472.1, ENSRNOT00000139898.1
    Conserved Domains (3) summary
    PHA02876
    Location:26 → 215
    PHA02876; ankyrin repeat protein; Provisional
    cd03727
    Location:245 → 287
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:56 → 83
    ANK; ANK repeat [structural motif]

  3. XM_006242329.4 → XP_006242391.1  ankyrin repeat and SOCS box protein 8 isoform X2

    See identical proteins and their annotated locations for XP_006242391.1

    UniProtKB/TrEMBL
    A0A0G2JWD3, B5DF17, F7F2V9
    Conserved Domains (3) summary
    PHA02876
    Location:26 → 215
    PHA02876; ankyrin repeat protein; Provisional
    cd03727
    Location:245 → 287
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:56 → 83
    ANK; ANK repeat [structural motif]

  4. XM_017594890.3 → XP_017450379.1  ankyrin repeat and SOCS box protein 8 isoform X3

    Conserved Domains (3) summary
    cd03727
    Location:184 → 226
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:24 → 54
    ANK; ANK repeat [structural motif]
    cl39094
    Location:8 → 120
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_063263669.1 → XP_063119739.1  ankyrin repeat and SOCS box protein 8 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JWD3, B5DF17, F7F2V9
Nucleotide Protein Strain
Heading Accession and Version

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