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ASB8 ankyrin repeat and SOCS box containing 8 [ Homo sapiens (human) ]

Gene ID: 140461, updated on 23-Nov-2021

Summary

Official Symbol
ASB8provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 8provided by HGNC
Primary source
HGNC:HGNC:17183
See related
Ensembl:ENSG00000177981 MIM:615053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP14212
Expression
Ubiquitous expression in heart (RPKM 11.8), kidney (RPKM 11.3) and 25 other tissues See more
Orthologs
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Genomic context

See ASB8 in Genome Data Viewer
Location:
12q13.11
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (48147789..48157515, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48541572..48551298, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SUMO specific peptidase 1 Neighboring gene V-type proton ATPase subunit F pseudogene Neighboring gene phosphofructokinase, muscle Neighboring gene microRNA 6505 Neighboring gene SCO1 cytochrome c oxidase assembly protein pseudogene Neighboring gene PHB1 pseudogene 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5540, FLJ21255

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ankyrin repeat and SOCS box protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319296.2NP_001306225.1  ankyrin repeat and SOCS box protein 8 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AF464877, BC001321, DA071750
    Consensus CDS
    CCDS8761.1
    UniProtKB/Swiss-Prot
    Q9H765
    Conserved Domains (3) summary
    PHA02876
    Location:26215
    PHA02876; ankyrin repeat protein; Provisional
    cd03727
    Location:245287
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:5683
    ANK; ANK repeat [structural motif]
  2. NM_001319297.2NP_001306226.1  ankyrin repeat and SOCS box protein 8 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AF464877, AK289957, BC001321
    Consensus CDS
    CCDS8761.1
    UniProtKB/Swiss-Prot
    Q9H765
    Related
    ENSP00000445622.1, ENST00000536549.5
    Conserved Domains (3) summary
    PHA02876
    Location:26215
    PHA02876; ankyrin repeat protein; Provisional
    cd03727
    Location:245287
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:5683
    ANK; ANK repeat [structural motif]
  3. NM_001319298.2NP_001306227.1  ankyrin repeat and SOCS box protein 8 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' UTR, contains an alternate exon in the 5' region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 4 and 5 encode the same isoform (b).
    Source sequence(s)
    AF464877, BC001321, BP372866
    UniProtKB/Swiss-Prot
    Q9H765
    Conserved Domains (3) summary
    cd03727
    Location:184226
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:2454
    ANK; ANK repeat [structural motif]
    cl39094
    Location:8120
    Ank_2; Ankyrin repeats (3 copies)
  4. NM_001319299.2NP_001306228.1  ankyrin repeat and SOCS box protein 8 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon and uses an alternate splice site in the 5' UTR, contains an alternate exon in the 5' region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a. Variants 4 and 5 encode the same isoform (b).
    Source sequence(s)
    AF464877, BC001321, DA979010
    UniProtKB/Swiss-Prot
    Q9H765
    Conserved Domains (3) summary
    cd03727
    Location:184226
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:2454
    ANK; ANK repeat [structural motif]
    cl39094
    Location:8120
    Ank_2; Ankyrin repeats (3 copies)
  5. NM_001319300.2NP_001306229.1  ankyrin repeat and SOCS box protein 8 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon in the 5' UTR and contains an alternate exon in the 3' region, which results in a frameshift, compared to variant 1. The encoded isoform (c) has a shorter, distinct C-terminus compared to isoform a. Variants 6 and 7 encode the same isoform (c).
    Source sequence(s)
    AF464877, BC001321, BP195070
    Consensus CDS
    CCDS81686.1
    UniProtKB/Swiss-Prot
    Q9H765
    UniProtKB/TrEMBL
    F5GYF0
    Related
    ENSP00000438498.1, ENST00000536953.5
    Conserved Domains (2) summary
    cd00204
    Location:3477
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:5177
    ANK; ANK repeat [structural motif]
  6. NM_001319301.2NP_001306230.1  ankyrin repeat and SOCS box protein 8 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate exon and uses an alternate splice site in the 5' UTR and contains an alternate exon in the 3' region, which results in a frameshift, compared to variant 1. The encoded isoform (c) has a shorter, distinct C-terminus compared to isoform a. Variants 6 and 7 encode the same isoform (c).
    Source sequence(s)
    AF464877, BC001321, BP210910
    Consensus CDS
    CCDS81686.1
    UniProtKB/Swiss-Prot
    Q9H765
    UniProtKB/TrEMBL
    F5GYF0
    Related
    ENSP00000440773.1, ENST00000535055.5
    Conserved Domains (2) summary
    cd00204
    Location:3477
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:5177
    ANK; ANK repeat [structural motif]
  7. NM_024095.5NP_077000.1  ankyrin repeat and SOCS box protein 8 isoform a

    See identical proteins and their annotated locations for NP_077000.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AF464877, BC001321, BM837218
    Consensus CDS
    CCDS8761.1
    UniProtKB/Swiss-Prot
    Q9H765
    Related
    ENSP00000320893.3, ENST00000317697.8
    Conserved Domains (3) summary
    PHA02876
    Location:26215
    PHA02876; ankyrin repeat protein; Provisional
    cd03727
    Location:245287
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:5683
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    48147789..48157515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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