Cbarp CACN subunit beta associated regulatory protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cbarpprovided by RGD
Official Full Name: CACN subunit beta associated regulatory proteinprovided by RGD
Primary source: RGD:1307185
See related: EnsemblRapid:ENSRNOG00000024349 AllianceGenome:RGD:1307185
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dos
Summary: Predicted to enable transmembrane transporter binding activity. Involved in negative regulation of voltage-gated calcium channel activity. Colocalizes with secretory granule. Orthologous to human CBARP (CACN subunit beta associated regulatory protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 124.3), Adrenal (RPKM 29.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10217314..10225855)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9566637..9575204)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12433422..12441048)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Stk11 (e-PCR), detects polymorphism
- UniSTS:158764

D7Got1 (e-PCR)
- UniSTS:111827

BE110397 (e-PCR)
- UniSTS:245247

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-dependent calcium channel beta subunit-associated regulatory protein

Names: CACN beta subunit associated regulatory protein; calcium channel, voltage-dependent, beta subunit associated regulatory protein; downstream of Stk11; protein Dos

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108070.4 → NP_001101540.1 voltage-dependent calcium channel beta subunit-associated regulatory protein

See identical proteins and their annotated locations for NP_001101540.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6K8Q7, B5DFH0
NM_001388507.1 → NP_001375436.1 voltage-dependent calcium channel beta subunit-associated regulatory protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6K8Q7, B5DFH0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

10217314..10225855

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078984.2 → XP_038934912.1 voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X2

UniProtKB/TrEMBL

F1MAS1

Related

ENSRNOP00000057421.4, ENSRNOT00000060690.6
XM_039078983.2 → XP_038934911.1 voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X1
XM_039078985.2 → XP_038934913.1 voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X3