U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CBARP CACN subunit beta associated regulatory protein [ Homo sapiens (human) ]

Gene ID: 255057, updated on 26-Oct-2022

Summary

Official Symbol
CBARPprovided by HGNC
Official Full Name
CACN subunit beta associated regulatory proteinprovided by HGNC
Primary source
HGNC:HGNC:28617
See related
Ensembl:ENSG00000099625 AllianceGenome:HGNC:28617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOS; BARP; C19orf26
Summary
Predicted to enable transmembrane transporter binding activity. Predicted to be involved in negative regulation of calcium ion-dependent exocytosis and negative regulation of voltage-gated calcium channel activity. Predicted to be located in synaptic vesicle membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Predicted to colocalize with growth cone and secretory granule. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 2.8), adrenal (RPKM 1.1) and 12 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CBARP in Genome Data Viewer
Location:
19p13.3
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1228287..1238502, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1196845..1206563, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1228286..1238004, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 11 Neighboring gene Sharpr-MPRA regulatory region 9448 Neighboring gene serine/threonine kinase 11 intron 3 Alu-mediated recombination region Neighboring gene CBARP divergent transcript Neighboring gene ATP synthase F1 subunit delta Neighboring gene uncharacterized LOC102723811

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC40084

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane transporter binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
colocalizes_with growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in secretory granule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
voltage-dependent calcium channel beta subunit-associated regulatory protein
Names
CACN beta subunit associated regulatory protein
VGCC beta-anchoring and -regulatory protein
calcium channel, voltage-dependent, beta subunit associated regulatory protein
downstream of Stk11
protein Dos

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393918.1NP_001380847.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004221
    Consensus CDS
    CCDS92477.1
    UniProtKB/Swiss-Prot
    O43385
    Related
    ENSP00000497208.1, ENST00000650044.2
  2. NM_152769.3NP_689982.3  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform 2

    See identical proteins and their annotated locations for NP_689982.3

    Status: VALIDATED

    Source sequence(s)
    AC004221, AW163263, BC028156, BM263341, BM743507, BX094586, CK824551
    Consensus CDS
    CCDS12057.2
    UniProtKB/Swiss-Prot
    Q8N350
    Related
    ENSP00000465260.1, ENST00000590083.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    1228287..1238502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026555.2XP_016882044.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X1

  2. XM_017026556.2XP_016882045.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X2

  3. XM_017026558.1XP_016882047.1  voltage-dependent calcium channel beta subunit-associated regulatory protein isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    1196845..1206563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)