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Slc22a18 solute carrier family 22, member 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309131, updated on 5-Mar-2024

Summary

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Official Symbol
Slc22a18provided by RGD
Official Full Name
solute carrier family 22, member 18provided by RGD
Primary source
RGD:1303323
See related
Ensembl:ENSRNOG00000020562 AllianceGenome:RGD:1303323
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transmembrane transporter activity and ubiquitin protein ligase binding activity. Predicted to be involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Predicted to be located in apical plasma membrane; cytoplasm; and nuclear envelope. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human SLC22A18 (solute carrier family 22 member 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 498.5), Kidney (RPKM 422.0) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc22a18 in Genome Data Viewer
Location:
1q42
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (208100032..208124382)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (198670626..198694977)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216676330..216700632)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily Q member 1 Neighboring gene uncharacterized LOC120099963 Neighboring gene cyclin-dependent kinase inhibitor 1C Neighboring gene pleckstrin homology-like domain, family A, member 2 Neighboring gene nucleosome assembly protein 1-like 4 Neighboring gene small nucleolar RNA, H/ACA box 54

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results reveal a novel link between Slc22a18 and fat accumulation and suggest that this gene could be a new therapeutic target in obesity.
    Title: A novel link between Slc22a18 and fat accumulation revealed by a mutation in the spontaneously hypertensive rat.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94186

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 22 member 18
Names
ORCTL-2
organic cation transporter-like protein 2
solute carrier family 22 (organic cation transporter), member 18
tumor suppressing subtransferable candidate 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004260.1 → NP_001004260.1  solute carrier family 22 member 18

    See identical proteins and their annotated locations for NP_001004260.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079159
    UniProtKB/Swiss-Prot
    Q6AY78
    UniProtKB/TrEMBL
    A0A0G2JSS3
    Related
    ENSRNOP00000027925.3, ENSRNOT00000027925.5
    Conserved Domains (2) summary
    cd06174
    Location:18 → 382
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:18 → 369
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    208100032..208124382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230775.5 → XP_006230837.1  solute carrier family 22 member 18 isoform X1

    See identical proteins and their annotated locations for XP_006230837.1

    UniProtKB/Swiss-Prot
    Q6AY78
    UniProtKB/TrEMBL
    A0A0G2JSS3
    Conserved Domains (2) summary
    cd06174
    Location:18 → 382
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:18 → 369
    MFS_1; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY78.2 GenPept UniProtKB/Swiss-Prot:Q6AY78

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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