U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cd226 CD226 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 307199, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Cd226provided by RGD
Official Full Name
CD226 moleculeprovided by RGD
Primary source
RGD:1311513
See related
EnsemblRapid:ENSRNOG00000038197 AllianceGenome:RGD:1311513
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable integrin binding activity and protein kinase binding activity. Predicted to be involved in positive regulation of immune response; positive regulation of interferon-gamma production; and positive regulation of mast cell activation. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane. Orthologous to human CD226 (CD226 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 94.0), Thymus (RPKM 74.3) and 7 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
18q13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (84723330..84819836)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (82449924..82545107)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (86299392..86394772)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483073 Neighboring gene snRNA-activating protein complex subunit 5-like Neighboring gene prothymosin alpha like 3 Neighboring gene docking protein 6 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CD226 Gly307Ser association with neuromyelitis optica in Southern Han Chinese. Liu C, et al. Can J Neurol Sci, 2012 Jul. PMID 22728856
  2. Identification and characterization of murine DNAM-1 (CD226) and its poliovirus receptor family ligands. Tahara-Hanaoka S, et al. Biochem Biophys Res Commun, 2005 Apr 15. PMID 15752754
  3. The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions. Chan CJ, et al. Nat Immunol, 2014 May. PMID 24658051
  4. Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. Bottino C, et al. J Exp Med, 2003 Aug 18. PMID 12913096, Free PMC Article
  5. Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. Bachelet I, et al. J Biol Chem, 2006 Sep 15. PMID 16831868

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. his study showed that CD226 Gly307Ser may correlate with risk of neuromyelitis optica in Southern Han Chinese.
    Title: CD226 Gly307Ser association with neuromyelitis optica in Southern Han Chinese.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of immunoglobulin mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of immunoglobulin mediated immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mast cell activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of natural killer cell cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
CD226 antigen

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107370.1 → NP_001100840.1  CD226 antigen precursor

    See identical proteins and their annotated locations for NP_001100840.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474021
    UniProtKB/TrEMBL
    A6K5P0, D3ZS97
    Related
    ENSRNOP00000054956.2, ENSRNOT00000058152.5
    Conserved Domains (3) summary
    cd05889
    Location:44 → 141
    Ig1_DNAM-1_like; First immunoglobulin (Ig) domain of DNAX accessory molecule 1 (DNAM-1, also known as CD226) and similar proteins
    smart00410
    Location:152 → 255
    IG_like; Immunoglobulin like
    cl11960
    Location:151 → 239
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    84723330..84819836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096759.2 → XP_038952687.1  CD226 antigen isoform X1

    UniProtKB/TrEMBL
    A6K5P1
    Related
    ENSRNOP00000111825.1, ENSRNOT00000172632.1
    Conserved Domains (1) summary
    cd05889
    Location:17 → 128
    IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains

  2. XM_006255028.5 → XP_006255090.1  CD226 antigen isoform X1

    See identical proteins and their annotated locations for XP_006255090.1

    UniProtKB/TrEMBL
    A6K5P1
    Conserved Domains (1) summary
    cd05889
    Location:17 → 128
    IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains

  3. XM_006255031.5 → XP_006255093.1  CD226 antigen isoform X1

    See identical proteins and their annotated locations for XP_006255093.1

    UniProtKB/TrEMBL
    A6K5P1
    Conserved Domains (1) summary
    cd05889
    Location:17 → 128
    IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains

  4. XM_039096758.2 → XP_038952686.1  CD226 antigen isoform X1

    UniProtKB/TrEMBL
    A6K5P1
    Conserved Domains (1) summary
    cd05889
    Location:17 → 128
    IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains

  5. XM_063277286.1 → XP_063133356.1  CD226 antigen isoform X1

    UniProtKB/TrEMBL
    A6K5P1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous