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Cd226 CD226 antigen [ Mus musculus (house mouse) ]

Gene ID: 225825, updated on 8-Nov-2022

Summary

Official Symbol
Cd226provided by MGI
Official Full Name
CD226 antigenprovided by MGI
Primary source
MGI:MGI:3039602
See related
Ensembl:ENSMUSG00000034028 AllianceGenome:MGI:3039602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pta1; DNAM1; DNAM-1; TLiSA1
Summary
Predicted to enable integrin binding activity and protein kinase binding activity. Acts upstream of or within positive regulation of interferon-gamma production and positive regulation of natural killer cell cytokine production. Located in external side of plasma membrane. Is expressed in embryo. Orthologous to human CD226 (CD226 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Cd226 in Genome Data Viewer
Location:
18; 18 E4
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (89195078..89290356)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (89176954..89272232)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 6 Neighboring gene microRNA 6359 Neighboring gene rotatin Neighboring gene docking protein 6 Neighboring gene predicted gene, 18279 Neighboring gene predicted gene, 41800

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of natural killer cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immunoglobulin mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of immunoglobulin mediated immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mast cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of mast cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of natural killer cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CD226 antigen
Names
platelet and T cell activation antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039149.1NP_001034238.1  CD226 antigen isoform b

    See identical proteins and their annotated locations for NP_001034238.1

    Status: VALIDATED

    Source sequence(s)
    AC116387, AF421199
    Consensus CDS
    CCDS29391.1
    UniProtKB/TrEMBL
    Q8K4E3
    Related
    ENSMUSP00000095104.3, ENSMUST00000097496.4
    Conserved Domains (2) summary
    smart00410
    Location:26124
    IG_like; Immunoglobulin like
    cl11960
    Location:24113
    Ig; Immunoglobulin domain
  2. NM_178687.2NP_848802.2  CD226 antigen isoform a precursor

    See identical proteins and their annotated locations for NP_848802.2

    Status: VALIDATED

    Source sequence(s)
    AC116387, AK140349
    Consensus CDS
    CCDS29392.1
    UniProtKB/Swiss-Prot
    Q8K4F0
    UniProtKB/TrEMBL
    Q5DW69
    Related
    ENSMUSP00000043551.6, ENSMUST00000037142.13
    Conserved Domains (3) summary
    cd00096
    Location:130134
    Ig; Ig strand A [structural motif]
    cd05889
    Location:17128
    IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains
    cl11960
    Location:137225
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    89195078..89290356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526463.1XP_006526526.1  CD226 antigen isoform X4

    Conserved Domains (1) summary
    cl11960
    Location:21110
    Ig; Immunoglobulin domain
  2. XM_006526461.1XP_006526524.1  CD226 antigen isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:52149
    Ig; Immunoglobulin domain
  3. XM_017317894.1XP_017173383.1  CD226 antigen isoform X3

    Conserved Domains (1) summary
    cl11960
    Location:45134
    Ig; Immunoglobulin domain
  4. XM_036161134.1XP_036017027.1  CD226 antigen isoform X2

    UniProtKB/Swiss-Prot
    Q8K4F0
    UniProtKB/TrEMBL
    Q5DW69
    Related
    ENSMUSP00000158324.2, ENSMUST00000236828.2
    Conserved Domains (3) summary
    cd00096
    Location:130134
    Ig; Ig strand A [structural motif]
    cd05889
    Location:17128
    IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains
    cl11960
    Location:137225
    Ig; Immunoglobulin domain
  5. XM_006526464.5XP_006526527.1  CD226 antigen isoform X5

    See identical proteins and their annotated locations for XP_006526527.1

    UniProtKB/TrEMBL
    Q8K4E2
    Related
    ENSMUSP00000158239.2, ENSMUST00000236452.2
  6. XM_006526462.5XP_006526525.1  CD226 antigen isoform X2

    See identical proteins and their annotated locations for XP_006526525.1

    UniProtKB/Swiss-Prot
    Q8K4F0
    UniProtKB/TrEMBL
    Q5DW69
    Conserved Domains (3) summary
    cd00096
    Location:130134
    Ig; Ig strand A [structural motif]
    cd05889
    Location:17128
    IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains
    cl11960
    Location:137225
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039148.1: Suppressed sequence

    Description
    NM_001039148.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.