U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cd226 CD226 antigen [ Mus musculus (house mouse) ]

Gene ID: 225825, updated on 23-Nov-2023

Summary

Go to the top of the page Help
Official Symbol
Cd226provided by MGI
Official Full Name
CD226 antigenprovided by MGI
Primary source
MGI:MGI:3039602
See related
Ensembl:ENSMUSG00000034028 AllianceGenome:MGI:3039602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pta1; DNAM1; DNAM-1; TLiSA1
Summary
Predicted to enable integrin binding activity and protein kinase binding activity. Acts upstream of or within positive regulation of interferon-gamma production and positive regulation of natural killer cell cytokine production. Located in external side of plasma membrane. Is expressed in embryo. Orthologous to human CD226 (CD226 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cd226 in Genome Data Viewer
Location:
18 E4; 18 59.05 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (89195078..89290356)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (89176954..89272232)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 6 Neighboring gene microRNA 6359 Neighboring gene rotatin Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:89509927-89510110 Neighboring gene docking protein 6 Neighboring gene predicted gene, 18279 Neighboring gene predicted gene, 41800

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CD226 deficiency attenuates cardiac early pathological remodeling and dysfunction via decreasing inflammatory macrophage proportion and macrophage glycolysis in STZ-induced diabetic mice. Hou Y, et al. FASEB J, 2023 Aug. PMID 37392373
  2. Ablation of CD226 on CD4(+) T cells modulates asthma progress associated with altered IL-10 response and gut microbiota. Xie Y, et al. Int Immunopharmacol, 2023 May. PMID 36989896
  3. [Knockout of CD226 alleviates depression-like behavior induced by chronic restraint stress in mice by modulating the ratio of immune cells in spleen and intestine]. Wang T, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2023 Mar. PMID 36946349
  4. CD226 knockout reduces the development of CD8+ T by impairing the TCR sensitivity of double-positive thymocytes. Ma J, et al. Immunology, 2023 May. PMID 36420662
  5. [DNAM-1 regulates the proliferation and function of T regulatory type 1 cells via the IL-2/STAT5 pathway]. Wang N, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2022 Sep 20. PMID 36210700, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions.
    Title: CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions.
  2. Integrated single-cell and bulk sequencing analyses with experimental validation identify the prognostic and immunological implications of CD226 in pan-cancer.
    Title: Integrated single-cell and bulk sequencing analyses with experimental validation identify the prognostic and immunological implications of CD226 in pan-cancer.
  3. Competitive binding of CD226/TIGIT with poliovirus receptor regulates macrophage polarization and is involved in vascularized skin graft rejection.
    Title: Competitive binding of CD226/TIGIT with poliovirus receptor regulates macrophage polarization and is involved in vascularized skin graft rejection.
  4. CD226 deficiency attenuates cardiac early pathological remodeling and dysfunction via decreasing inflammatory macrophage proportion and macrophage glycolysis in STZ-induced diabetic mice.
    Title: CD226 deficiency attenuates cardiac early pathological remodeling and dysfunction via decreasing inflammatory macrophage proportion and macrophage glycolysis in STZ-induced diabetic mice.
  5. Ablation of CD226 on CD4[+] T cells modulates asthma progress associated with altered IL-10 response and gut microbiota.
    Title: Ablation of CD226 on CD4(+) T cells modulates asthma progress associated with altered IL-10 response and gut microbiota.
  6. CD226 knockout reduces the development of CD8+ T by impairing the TCR sensitivity of double-positive thymocytes.
    Title: CD226 knockout reduces the development of CD8+ T by impairing the TCR sensitivity of double-positive thymocytes.
  7. [Knockout of CD226 alleviates depression-like behavior induced by chronic restraint stress in mice by modulating the ratio of immune cells in spleen and intestine].
    Title: [Knockout of CD226 alleviates depression-like behavior induced by chronic restraint stress in mice by modulating the ratio of immune cells in spleen and intestine].
  8. [DNAM-1 regulates the proliferation and function of T regulatory type 1 cells via the IL-2/STAT5 pathway].
    Title: [DNAM-1 regulates the proliferation and function of T regulatory type 1 cells via the IL-2/STAT5 pathway].
  9. Loss of CD226 protects apolipoprotein E-deficient mice from diet-induced atherosclerosis.
    Title: Loss of CD226 protects apolipoprotein E-deficient mice from diet-induced atherosclerosis.
  10. DNAM-1 promotes inflammation-driven tumor development via enhancing IFN-gamma production.
    Title: DNAM-1 promotes inflammation-driven tumor development via enhancing IFN-γ production.
Submit: New GeneRIF Correction See all GeneRIFs (58)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of natural killer cell cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of immunoglobulin mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of immunoglobulin mediated immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mast cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mast cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of natural killer cell cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of natural killer cell cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type II interferon production IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
CD226 antigen
Names
platelet and T cell activation antigen 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039149.1 → NP_001034238.1  CD226 antigen isoform b

    See identical proteins and their annotated locations for NP_001034238.1

    Status: VALIDATED

    Source sequence(s)
    AC116387, AF421199
    Consensus CDS
    CCDS29391.1
    UniProtKB/TrEMBL
    Q8K4E3
    Related
    ENSMUSP00000095104.3, ENSMUST00000097496.4
    Conserved Domains (2) summary
    smart00410
    Location:26 → 124
    IG_like; Immunoglobulin like
    cl11960
    Location:24 → 113
    Ig; Immunoglobulin domain

  2. NM_178687.2 → NP_848802.2  CD226 antigen isoform a precursor

    See identical proteins and their annotated locations for NP_848802.2

    Status: VALIDATED

    Source sequence(s)
    AC116387, AK140349
    Consensus CDS
    CCDS29392.1
    UniProtKB/Swiss-Prot
    Q8K4F0
    UniProtKB/TrEMBL
    Q5DW69
    Related
    ENSMUSP00000043551.6, ENSMUST00000037142.13
    Conserved Domains (3) summary
    cd00096
    Location:130 → 134
    Ig; Ig strand A [structural motif]
    cd05889
    Location:17 → 128
    IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains
    cl11960
    Location:137 → 225
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    89195078..89290356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526463.1 → XP_006526526.1  CD226 antigen isoform X4

    Conserved Domains (1) summary
    cl11960
    Location:21 → 110
    Ig; Immunoglobulin domain

  2. XM_006526461.1 → XP_006526524.1  CD226 antigen isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:52 → 149
    Ig; Immunoglobulin domain

  3. XM_017317894.1 → XP_017173383.1  CD226 antigen isoform X3

    Conserved Domains (1) summary
    cl11960
    Location:45 → 134
    Ig; Immunoglobulin domain

  4. XM_036161134.1 → XP_036017027.1  CD226 antigen isoform X2

    UniProtKB/Swiss-Prot
    Q8K4F0
    UniProtKB/TrEMBL
    Q5DW69
    Related
    ENSMUSP00000158324.2, ENSMUST00000236828.2
    Conserved Domains (3) summary
    cd00096
    Location:130 → 134
    Ig; Ig strand A [structural motif]
    cd05889
    Location:17 → 128
    IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains
    cl11960
    Location:137 → 225
    Ig; Immunoglobulin domain

  5. XM_006526464.5 → XP_006526527.1  CD226 antigen isoform X5

    See identical proteins and their annotated locations for XP_006526527.1

    UniProtKB/TrEMBL
    Q8K4E2
    Related
    ENSMUSP00000158239.2, ENSMUST00000236452.2

  6. XM_006526462.5 → XP_006526525.1  CD226 antigen isoform X2

    See identical proteins and their annotated locations for XP_006526525.1

    UniProtKB/Swiss-Prot
    Q8K4F0
    UniProtKB/TrEMBL
    Q5DW69
    Conserved Domains (3) summary
    cd00096
    Location:130 → 134
    Ig; Ig strand A [structural motif]
    cd05889
    Location:17 → 128
    IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains
    cl11960
    Location:137 → 225
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039148.1: Suppressed sequence

    Description
    NM_001039148.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4F0.1 GenPept UniProtKB/Swiss-Prot:Q8K4F0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous