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Syap1 synapse associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302678, updated on 13-Apr-2024

Summary

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Official Symbol
Syap1provided by RGD
Official Full Name
synapse associated protein 1provided by RGD
Primary source
RGD:1303113
See related
Ensembl:ENSRNOG00000004304 AllianceGenome:RGD:1303113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including TORC2 signaling; cellular response to growth factor stimulus; and cellular response to peptide hormone stimulus. Predicted to be located in several cellular components, including growth cone; perikaryon; and synaptic membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to be active in Golgi apparatus; nucleus; and synapse. Orthologous to human SYAP1 (synapse associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 268.4), Adrenal (RPKM 187.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Syap1 in Genome Data Viewer
Location:
Xq14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (35423947..35458472)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (31792180..31826672)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (33528071..33562584)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene CTP synthase 2 Neighboring gene S100 calcium binding protein G Neighboring gene ornithine decarboxylase 1, pseudogene 2 Neighboring gene U6 spliceosomal RNA Neighboring gene heterogeneous nuclear ribonucleoprotein D, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Initial characterization of a Syap1 knock-out mouse and distribution of Syap1 in mouse brain and cultured motoneurons. Schmitt D, et al. Histochem Cell Biol, 2016 Oct. PMID 27344443, Free PMC Article
  2. BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. Yao Y, et al. Sci Signal, 2013 Jan 8. PMID 23300339, Free PMC Article
  3. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636
  4. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94115

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TORC2 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to insulin-like growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to platelet-derived growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of short-term neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
synapse-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395553.1 → NP_001382482.1  synapse-associated protein 1

    Status: VALIDATED

    Source sequence(s)
    FM069627, FN805488, JAXUCZ010000021
    UniProtKB/TrEMBL
    A6K2N4, F7F350, Q6AYB6
    Related
    ENSRNOP00000006584.5, ENSRNOT00000006584.7
    Conserved Domains (1) summary
    smart00751
    Location:169 → 219
    BSD; domain in transcription factors and synapse-associated proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    35423947..35458472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099662.2 → XP_038955590.1  synapse-associated protein 1 isoform X1

    Conserved Domains (1) summary
    smart00751
    Location:169 → 219
    BSD; domain in transcription factors and synapse-associated proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001004253.1: Suppressed sequence

    Description
    NM_001004253.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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