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Clk1 CDC-like kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301434, updated on 11-Apr-2024

Summary

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Official Symbol
Clk1provided by RGD
Official Full Name
CDC-like kinase 1provided by RGD
Primary source
RGD:1311469
See related
Ensembl:ENSRNOG00000025768 AllianceGenome:RGD:1311469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within protein phosphorylation. Located in cytoplasm. Orthologous to human CLK1 (CDC like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 997.3), Spleen (RPKM 804.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Clk1 in Genome Data Viewer
Location:
9q31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67441962..67453180, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (59947774..59959002, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65296777..65308017, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690538 Neighboring gene aldehyde oxidase 2 Neighboring gene basic leucine zipper and W2 domains 1 Neighboring gene uncharacterized LOC134480578 Neighboring gene peptidylprolyl isomerase like 3 Neighboring gene NGG1 interacting factor 3 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A new self-attenuated therapeutic influenza vaccine that uses host cell-restricted attenuation by artificial microRNAs. Wen K, et al. Int J Pharm, 2022 Jan 25. PMID 34883209, Free PMC Article
  2. Biochemical characterization and localization of the dual specificity kinase CLK1. Menegay HJ, et al. J Cell Sci, 2000 Sep. PMID 10954422
  3. STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases. Howell BW, et al. Mol Cell Biol, 1991 Jan. PMID 1986248, Free PMC Article
  4. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. Eisenreich A, et al. Circ Res, 2009 Mar 13. PMID 19168442
  5. The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. Moeslein FM, et al. J Biol Chem, 1999 Sep 17. PMID 10480872

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in peptidyl-tyrosine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual specificity protein kinase CLK1
NP_001100383.2
XP_063123017.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106913.2 → NP_001100383.2  dual specificity protein kinase CLK1

    See identical proteins and their annotated locations for NP_001100383.2

    Status: VALIDATED

    Source sequence(s)
    AA923848, BC081942, CV127206
    UniProtKB/TrEMBL
    A6IP60, D4ADG3
    Related
    ENSRNOP00000038335.4, ENSRNOT00000030934.7
    Conserved Domains (2) summary
    smart00220
    Location:160 → 476
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14213
    Location:147 → 476
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    67441962..67453180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266947.1 → XP_063123017.1  dual specificity protein kinase CLK1 isoform X1

    UniProtKB/TrEMBL
    A6IP62
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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