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Clk1 CDC-like kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 12747, updated on 5-Jan-2023

Summary

Official Symbol
Clk1provided by MGI
Official Full Name
CDC-like kinase 1provided by MGI
Primary source
MGI:MGI:107403
See related
Ensembl:ENSMUSG00000026034 AllianceGenome:MGI:107403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
STY
Summary
Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Acts upstream of or within protein phosphorylation. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; neural retina; and thyroid gland. Orthologous to human CLK1 (CDC like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 71.4), limb E14.5 (RPKM 59.9) and 23 other tissues See more
Orthologs
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Genomic context

See Clk1 in Genome Data Viewer
Location:
1 C1.3; 1 29.09 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58451147..58463247, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58411988..58424088, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27 pseudogene Neighboring gene predicted gene, 53481 Neighboring gene basic leucine zipper and W2 domains 1 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 3 Neighboring gene Ngg1 interacting factor 3-like 1 (S. pombe) Neighboring gene predicted gene, 23966 Neighboring gene origin recognition complex, subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity protein kinase CLK1
Names
protein kinase STY
NP_001036099.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042634.2NP_001036099.1  dual specificity protein kinase CLK1

    See identical proteins and their annotated locations for NP_001036099.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC121091, AK135765
    Consensus CDS
    CCDS35577.1
    UniProtKB/Swiss-Prot
    P22518, Q3UXB6
    Related
    ENSMUSP00000034868.8, ENSMUST00000034868.14
    Conserved Domains (2) summary
    smart00220
    Location:160476
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14213
    Location:147476
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

RNA

  1. NR_027853.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC121091
    Related
    ENSMUST00000148330.8
  2. NR_027854.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) retains several introns, compared to variant 1. The transcript is sufficiently abundant to represent as a RefSeq record; however, the variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC121091, BC062887

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58451147..58463247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_009905.2: Suppressed sequence

    Description
    NM_009905.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.