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Ppm1j protein phosphatase, Mg2+/Mn2+ dependent, 1J [ Rattus norvegicus (Norway rat) ]

Gene ID: 295341, updated on 3-Apr-2024

Summary

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Official Symbol
Ppm1jprovided by RGD
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent, 1Jprovided by RGD
Primary source
RGD:1359104
See related
Ensembl:ENSRNOG00000012481 AllianceGenome:RGD:1359104
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in protein dephosphorylation. Orthologous to human PPM1J (protein phosphatase, Mg2+/Mn2+ dependent 1J). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 96.5), Testes (RPKM 61.9) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (194966854..194972228)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (192278597..192283883)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (207263307..207268601)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350080 Neighboring gene uncharacterized LOC134485945 Neighboring gene TAFA chemokine like family member 3 Neighboring gene ras homolog family member C Neighboring gene Mov10 RNA helicase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9. Kashiwaba M, et al. FEBS Lett, 2003 Mar 13. PMID 12633878
  2. Molecular cloning of PP2Ceta, a novel member of the protein phosphatase 2C family. Komaki K, et al. Biochim Biophys Acta, 2003 Nov 30. PMID 14654243
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC95205

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein phosphatase 1J
Names
PP2C-zeta
protein phosphatase 2C zeta
NP_001005540.1
XP_008759602.1
XP_008759603.1
XP_063137710.1
XP_063137711.1
XP_063137712.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005540.1 → NP_001005540.1  protein phosphatase 1J

    See identical proteins and their annotated locations for NP_001005540.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082053
    UniProtKB/Swiss-Prot
    Q641Y6
    UniProtKB/TrEMBL
    A0A8I5ZXT1, A6K3P4
    Related
    ENSRNOP00000079348.1, ENSRNOT00000110381.1
    Conserved Domains (1) summary
    cd00143
    Location:105 → 496
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    194966854..194972228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281641.1 → XP_063137711.1  protein phosphatase 1J isoform X4

  2. XM_008761381.4 → XP_008759603.1  protein phosphatase 1J isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZXT1
    Conserved Domains (1) summary
    cd00143
    Location:123 → 478
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

  3. XM_008761380.4 → XP_008759602.1  protein phosphatase 1J isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHJ9, A0A8I5ZXT1
    Related
    ENSRNOP00000016833.5
    Conserved Domains (1) summary
    cd00143
    Location:123 → 514
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

  4. XM_063281642.1 → XP_063137712.1  protein phosphatase 1J isoform X5

  5. XM_063281640.1 → XP_063137710.1  protein phosphatase 1J isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZMI9

RNA

  1. XR_005500269.2 RNA Sequence

  2. XR_005500270.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q641Y6.1 GenPept UniProtKB/Swiss-Prot:Q641Y6

Gene LinkOut

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