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PPM1J protein phosphatase, Mg2+/Mn2+ dependent 1J [ Homo sapiens (human) ]

Gene ID: 333926, updated on 23-Nov-2021

Summary

Official Symbol
PPM1Jprovided by HGNC
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent 1Jprovided by HGNC
Primary source
HGNC:HGNC:20785
See related
Ensembl:ENSG00000155367 MIM:609957
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP2CZ; PPP2CZ; PP2Czeta; PP2C-zeta
Summary
This gene encodes the serine/threonine protein phosphatase. The mouse homolog of this gene apparently belongs to the protein phosphatase 2C family of genes. The exact function of this gene is not yet known. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 22.7), skin (RPKM 8.1) and 5 other tissues See more
Orthologs
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Genomic context

See PPM1J in Genome Data Viewer
Location:
1p13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (112709998..112715332, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113252616..113257950, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene Sharpr-MPRA regulatory region 4682 Neighboring gene ras homolog family member C Neighboring gene Sharpr-MPRA regulatory region 11832 Neighboring gene PPM1J divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: RHOC

Homology

Clone Names

  • FLJ35951, MGC19531, MGC90149, DKFZp434P1514

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein phosphatase 1J
Names
protein phosphatase 1J (PP2C domain containing)
protein phosphatase 2C zeta
NP_005158.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005167.7NP_005158.5  protein phosphatase 1J

    See identical proteins and their annotated locations for NP_005158.5

    Status: REVIEWED

    Source sequence(s)
    AL603832
    Consensus CDS
    CCDS855.2
    UniProtKB/Swiss-Prot
    Q5JR12
    Related
    ENSP00000308926.6, ENST00000309276.10
    Conserved Domains (1) summary
    cd00143
    Location:106498
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    112709998..112715332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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