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PPM1J protein phosphatase, Mg2+/Mn2+ dependent 1J [ Homo sapiens (human) ]

Gene ID: 333926, updated on 10-Dec-2024

Summary

Official Symbol
PPM1Jprovided by HGNC
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent 1Jprovided by HGNC
Primary source
HGNC:HGNC:20785
See related
Ensembl:ENSG00000155367 MIM:609957; AllianceGenome:HGNC:20785
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP2CZ; PPP2CZ; PP2Czeta; PP2C-zeta
Summary
This gene encodes the serine/threonine protein phosphatase. The mouse homolog of this gene apparently belongs to the protein phosphatase 2C family of genes. The exact function of this gene is not yet known. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 22.7), skin (RPKM 8.1) and 5 other tissues See more
Orthologs
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Genomic context

See PPM1J in Genome Data Viewer
Location:
1p13.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (112709998..112715332, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (112722547..112727883, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113252620..113257954, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1202 Neighboring gene Mov10 RNA helicase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113234976-113235476 Neighboring gene Sharpr-MPRA regulatory region 4682 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113242906-113243833 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113246858-113247412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1203 Neighboring gene ras homolog family member C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1518 Neighboring gene Sharpr-MPRA regulatory region 11832 Neighboring gene PPM1J divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1205 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:113266466-113266670 Neighboring gene TAFA chemokine like family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: RHOC

Clone Names

  • FLJ35951, MGC19531, MGC90149, DKFZp434P1514

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein phosphatase 1J
Names
protein phosphatase 1J (PP2C domain containing)
protein phosphatase 2C zeta
NP_005158.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005167.7NP_005158.5  protein phosphatase 1J

    See identical proteins and their annotated locations for NP_005158.5

    Status: REVIEWED

    Source sequence(s)
    AL603832
    Consensus CDS
    CCDS855.2
    UniProtKB/Swiss-Prot
    B3KSB7, Q5JR12, Q6DKJ7, Q96EZ7, Q9UF84
    Related
    ENSP00000308926.6, ENST00000309276.11
    Conserved Domains (1) summary
    cd00143
    Location:106498
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    112709998..112715332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    112722547..112727883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)