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Fndc3b fibronectin type III domain containing 3B [ Rattus norvegicus (Norway rat) ]

Gene ID: 294925, updated on 17-Aug-2024

Summary

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Official Symbol
Fndc3bprovided by RGD
Official Full Name
fibronectin type III domain containing 3Bprovided by RGD
Primary source
RGD:1311673
See related
EnsemblRapid:ENSRNOG00000024089 AllianceGenome:RGD:1311673
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311673
Summary
Predicted to act upstream of or within several processes, including negative regulation of osteoblast differentiation; substrate adhesion-dependent cell spreading; and type II pneumocyte differentiation. Predicted to be located in endoplasmic reticulum. Orthologous to human FNDC3B (fibronectin type III domain containing 3B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 184.7), Adrenal (RPKM 174.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q24
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (112240108..112546113, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (110311439..110617504, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (113109949..113415171, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene U1 small nuclear ribonucleoprotein C-like Neighboring gene growth hormone secretagogue receptor Neighboring gene uncharacterized LOC134485892 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene cyclin-dependent kinase 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Fad104, a positive regulator of adipogenesis, negatively regulates osteoblast differentiation. Kishimoto K, et al. Biochem Biophys Res Commun, 2010 Jun 25. PMID 20493170
  2. Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration. Nishizuka M, et al. Exp Cell Res, 2009 Mar 10. PMID 19138685
  3. The novel gene fad104, containing a fibronectin type III domain, has a significant role in adipogenesis. Tominaga K, et al. FEBS Lett, 2004 Nov 5. PMID 15527760
  4. Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation. Kishimoto K, et al. Exp Cell Res, 2011 Sep 10. PMID 21704616
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within fibroblast migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within type II pneumocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibronectin type III domain-containing protein 3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191704.1 → NP_001178633.1  fibronectin type III domain-containing protein 3B

    See identical proteins and their annotated locations for NP_001178633.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    D4A0W7
    Related
    ENSRNOP00000106352.1, ENSRNOT00000154172.1
    Conserved Domains (2) summary
    cd00063
    Location:674 → 765
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:889 → 950
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    112240108..112546113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281559.1 → XP_063137629.1  fibronectin type III domain-containing protein 3B isoform X2

    Related
    ENSRNOP00000098843.1, ENSRNOT00000152014.1

  2. XM_006232215.5 → XP_006232277.1  fibronectin type III domain-containing protein 3B isoform X1

    See identical proteins and their annotated locations for XP_006232277.1

    UniProtKB/TrEMBL
    D4A0W7
    Conserved Domains (2) summary
    cd00063
    Location:674 → 765
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:889 → 950
    fn3; Fibronectin type III domain

  3. XM_039101977.2 → XP_038957905.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/TrEMBL
    D4A0W7
    Conserved Domains (2) summary
    cd00063
    Location:674 → 765
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:889 → 950
    fn3; Fibronectin type III domain

  4. XM_006232216.5 → XP_006232278.1  fibronectin type III domain-containing protein 3B isoform X1

    See identical proteins and their annotated locations for XP_006232278.1

    UniProtKB/TrEMBL
    D4A0W7
    Conserved Domains (2) summary
    cd00063
    Location:674 → 765
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:889 → 950
    fn3; Fibronectin type III domain

  5. XM_063281557.1 → XP_063137627.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/TrEMBL
    D4A0W7

  6. XM_063281558.1 → XP_063137628.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/TrEMBL
    D4A0W7
Nucleotide Protein Strain
Heading Accession and Version

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