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FNDC3B fibronectin type III domain containing 3B [ Homo sapiens (human) ]

Gene ID: 64778, updated on 3-Jun-2018
Official Symbol
FNDC3Bprovided by HGNC
Official Full Name
fibronectin type III domain containing 3Bprovided by HGNC
Primary source
HGNC:HGNC:24670
See related
Ensembl:ENSG00000075420 MIM:611909; Vega:OTTHUMG00000156761
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAD104; PRO4979; YVTM2421
Expression
Ubiquitous expression in placenta (RPKM 15.6), thyroid (RPKM 11.7) and 25 other tissues See more
Orthologs
See FNDC3B in Genome Data Viewer
Location:
3q26.31
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (172039628..172400703)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (171757418..172118493)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TMEM212 antisense RNA 1 Neighboring gene uncharacterized LOC105374218 Neighboring gene uncharacterized LOC105374217 Neighboring gene FOXA motif-containing MPRA enhancer 130 Neighboring gene HNF1 motif-containing MPRA enhancer 67 Neighboring gene uncharacterized LOC107986153 Neighboring gene ribosomal protein S27a pseudogene 8 Neighboring gene RNA, 7SL, cytoplasmic 141, pseudogene Neighboring gene basic leucine zipper and W2 domains 1 pseudogene 1 Neighboring gene growth hormone secretagogue receptor

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
NHGRI GWA Catalog
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ23399, MGC10002, DKFZp762K137, DKFZp686D14170

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
fibronectin type III domain-containing protein 3B
Names
HCV NS5A-binding protein 37
factor for adipocyte differentiation 104

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135095.1NP_001128567.1  fibronectin type III domain-containing protein 3B

    See identical proteins and their annotated locations for NP_001128567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AB098597, AI417065, AK223599, AK314478
    Consensus CDS
    CCDS3217.1
    UniProtKB/Swiss-Prot
    Q53EP0
    Related
    ENSP00000338523.4, OTTHUMP00000210532, ENST00000336824.8, OTTHUMT00000345618
    Conserved Domains (2) summary
    cd00063
    Location:572666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:886947
    fn3; Fibronectin type III domain
  2. NM_022763.3NP_073600.3  fibronectin type III domain-containing protein 3B

    See identical proteins and their annotated locations for NP_073600.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AB098597, AI417065, AK223599, AK314478
    Consensus CDS
    CCDS3217.1
    UniProtKB/Swiss-Prot
    Q53EP0
    Related
    ENSP00000411242.2, OTTHUMP00000210535, ENST00000415807.6, OTTHUMT00000345621
    Conserved Domains (2) summary
    cd00063
    Location:572666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:886947
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    172039628..172400703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007062.1XP_016862551.1  fibronectin type III domain-containing protein 3B isoform X2

  2. XM_017007064.2XP_016862553.1  fibronectin type III domain-containing protein 3B isoform X4

  3. XM_024453717.1XP_024309485.1  fibronectin type III domain-containing protein 3B isoform X1

    Conserved Domains (2) summary
    cd00063
    Location:572666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:886947
    fn3; Fibronectin type III domain
  4. XM_024453716.1XP_024309484.1  fibronectin type III domain-containing protein 3B isoform X1

    Conserved Domains (2) summary
    cd00063
    Location:572666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:886947
    fn3; Fibronectin type III domain
  5. XM_017007063.1XP_016862552.1  fibronectin type III domain-containing protein 3B isoform X3

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