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FNDC3B fibronectin type III domain containing 3B [ Homo sapiens (human) ]

Gene ID: 64778, updated on 9-Sep-2025
Official Symbol
FNDC3Bprovided by HGNC
Official Full Name
fibronectin type III domain containing 3Bprovided by HGNC
Primary source
HGNC:HGNC:24670
See related
Ensembl:ENSG00000075420 MIM:611909; AllianceGenome:HGNC:24670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAD104; PRO4979; YVTM2421
Summary
Enables RNA binding activity. Predicted to act upstream of or within several processes, including negative regulation of osteoblast differentiation; substrate adhesion-dependent cell spreading; and type II pneumocyte differentiation. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in placenta (RPKM 15.6), thyroid (RPKM 11.7) and 25 other tissues See more
Orthologs
mouse all
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See FNDC3B in Genome Data Viewer
Location:
3q26.31
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (172039578..172401669)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (174823628..175186764)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (171757368..172119459)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TMEM212 antisense RNA 1 Neighboring gene uncharacterized LOC105374218 Neighboring gene uncharacterized LOC105374217 Neighboring gene Sharpr-MPRA regulatory region 13471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:171678336-171678836 Neighboring gene FOXA motif-containing MPRA enhancer 130 Neighboring gene NANOG hESC enhancer GRCh37_chr3:171727625-171728138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20816 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:171757188-171757855 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:171757856-171758522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20817 Neighboring gene HNF1 motif-containing MPRA enhancer 67 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20820 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:171854185-171855008 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:171858305-171859128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20821 Neighboring gene Sharpr-MPRA regulatory region 1756 Neighboring gene uncharacterized LOC124906304 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:171884751-171885290 Neighboring gene Sharpr-MPRA regulatory region 4529 Neighboring gene Sharpr-MPRA regulatory region 6188 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:171911885-171912075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:171927153-171927716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:171927717-171928279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20825 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:171940563-171941066 Neighboring gene Sharpr-MPRA regulatory region 15581 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:171973898-171974093 Neighboring gene RPS27A pseudogene 8 Neighboring gene RNA, 7SL, cytoplasmic 141, pseudogene Neighboring gene Sharpr-MPRA regulatory region 14584 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:172018611-172019279 Neighboring gene Sharpr-MPRA regulatory region 11565 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:172032476-172033374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:172165405-172166172 Neighboring gene basic leucine zipper and W2 domains 1 pseudogene 1 Neighboring gene growth hormone secretagogue receptor

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. FAD104, a regulator of adipogenesis, is a novel suppressor of TGF-β-mediated EMT in cervical cancer cells. Goto M, et al. Sci Rep, 2017 Nov 27. PMID 29180690, Free PMC Article
  2. Identification of Circ-FNDC3B, an Overexpressed circRNA in Abdominal Aortic Aneurysm, as a Regulator of Vascular Smooth Muscle Cells. Liu Y, et al. Int Heart J, 2021 Nov 30. PMID 34789642
  3. Identification of fibronectin type III domain containing 3B as a potential prognostic and therapeutic target for pancreatic cancer: a preliminary analysis. Wang Y, et al. Eur J Med Res, 2024 Apr 5. PMID 38581008, Free PMC Article
  4. NS5ABP37 inhibits liver cancer by impeding lipogenesis and cholesterogenesis. Feng S, et al. Cancer Sci, 2017 Jan. PMID 27862769, Free PMC Article
  5. circFNDC3B promotes esophageal squamous cell carcinoma progression by targeting MYO5A via miR-370-3p/miR-136-5p. Song D, et al. BMC Cancer, 2023 Sep 4. PMID 37667251, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of fibronectin type III domain containing 3B as a potential prognostic and therapeutic target for pancreatic cancer: a preliminary analysis.
    Title: Identification of fibronectin type III domain containing 3B as a potential prognostic and therapeutic target for pancreatic cancer: a preliminary analysis.
  2. circFNDC3B promotes esophageal squamous cell carcinoma progression by targeting MYO5A via miR-370-3p/miR-136-5p.
    Title: circFNDC3B promotes esophageal squamous cell carcinoma progression by targeting MYO5A via miR-370-3p/miR-136-5p.
  3. Lack of Association of Polymorphism Located Upstream of ABCA1 (rs2472493), in FNDC3B (rs7636836), and Near ANKRD55-MAP3K1 Genes (rs61275591) in Primary Open-Angle Glaucoma Patients of Saudi Origin.
    Title: Lack of Association of Polymorphism Located Upstream of ABCA1 (rs2472493), in FNDC3B (rs7636836), and Near ANKRD55-MAP3K1 Genes (rs61275591) in Primary Open-Angle Glaucoma Patients of Saudi Origin.
  4. Circ_0000285 regulates nasopharyngeal carcinoma progression through miR-1278/FNDC3B axis.
    Title: Circ_0000285 regulates nasopharyngeal carcinoma progression through miR-1278/FNDC3B axis.
  5. m[6]A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation.
    Title: m(6)A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation.
  6. Integrated machine learning methods identify FNDC3B as a potential prognostic biomarker and correlated with immune infiltrates in glioma.
    Title: Integrated machine learning methods identify FNDC3B as a potential prognostic biomarker and correlated with immune infiltrates in glioma.
  7. Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis.
    Title: Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis.
  8. Long Non-Coding RNA DUXAP8 Acts as an Oncogene in Sinonasal Squamous Cell Carcinoma Through miR-584-5p/FNDC3B Pathway.
    Title: Long Non-Coding RNA DUXAP8 Acts as an Oncogene in Sinonasal Squamous Cell Carcinoma Through miR-584-5p/FNDC3B Pathway.
  9. Hsa_circRNA_0001971 contributes to oral squamous cell carcinoma progression via miR-186-5p/Fibronectin type III domain containing 3B axis.
    Title: Hsa_circRNA_0001971 contributes to oral squamous cell carcinoma progression via miR-186-5p/Fibronectin type III domain containing 3B axis.
  10. Identification of Circ-FNDC3B, an Overexpressed circRNA in Abdominal Aortic Aneurysm, as a Regulator of Vascular Smooth Muscle Cells.
    Title: Identification of Circ-FNDC3B, an Overexpressed circRNA in Abdominal Aortic Aneurysm, as a Regulator of Vascular Smooth Muscle Cells.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
EBI GWAS Catalog
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ23399, MGC10002, DKFZp762K137, DKFZp686D14170

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
fibronectin type III domain-containing protein 3B
Names
HCV NS5A-binding protein 37
factor for adipocyte differentiation 104

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135095.2 → NP_001128567.1  fibronectin type III domain-containing protein 3B

    See identical proteins and their annotated locations for NP_001128567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AB098597, AC069259, AC069523, AI417065, AK223599, AK314478
    Consensus CDS
    CCDS3217.1
    UniProtKB/Swiss-Prot
    B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
    Related
    ENSP00000338523.4, ENST00000336824.8
    Conserved Domains (2) summary
    cd00063
    Location:572 → 666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:886 → 947
    fn3; Fibronectin type III domain

  2. NM_022763.4 → NP_073600.3  fibronectin type III domain-containing protein 3B

    See identical proteins and their annotated locations for NP_073600.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AB098597, AC069259, AC069523, AI417065, AK223599, AK314478
    Consensus CDS
    CCDS3217.1
    UniProtKB/Swiss-Prot
    B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
    Related
    ENSP00000411242.2, ENST00000415807.7
    Conserved Domains (2) summary
    cd00063
    Location:572 → 666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:886 → 947
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    172039578..172401669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007062.2 → XP_016862551.1  fibronectin type III domain-containing protein 3B isoform X2

    Related
    ENSP00000569219.1, ENST00000899160.1

  2. XM_017007064.3 → XP_016862553.1  fibronectin type III domain-containing protein 3B isoform X3

  3. XM_024453717.2 → XP_024309485.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
    Related
    ENSP00000569238.1, ENST00000899179.1
    Conserved Domains (2) summary
    cd00063
    Location:572 → 666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:886 → 947
    fn3; Fibronectin type III domain

  4. XM_047448756.1 → XP_047304712.1  fibronectin type III domain-containing protein 3B isoform X2

    Related
    ENSP00000617537.1, ENST00000947478.1

  5. XM_047448755.1 → XP_047304711.1  fibronectin type III domain-containing protein 3B isoform X2

    Related
    ENSP00000569239.1, ENST00000899180.1

  6. XM_047448752.1 → XP_047304708.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8

  7. XM_047448754.1 → XP_047304710.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8

  8. XM_047448757.1 → XP_047304713.1  fibronectin type III domain-containing protein 3B isoform X2

  9. XM_024453716.2 → XP_024309484.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
    Related
    ENSP00000569246.1, ENST00000899187.1
    Conserved Domains (2) summary
    cd00063
    Location:572 → 666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:886 → 947
    fn3; Fibronectin type III domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    174823628..175186764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347596.1 → XP_054203571.1  fibronectin type III domain-containing protein 3B isoform X2

  2. XM_054347601.1 → XP_054203576.1  fibronectin type III domain-containing protein 3B isoform X3

  3. XM_054347591.1 → XP_054203566.1  fibronectin type III domain-containing protein 3B isoform X1

  4. XM_054347598.1 → XP_054203573.1  fibronectin type III domain-containing protein 3B isoform X2

  5. XM_054347597.1 → XP_054203572.1  fibronectin type III domain-containing protein 3B isoform X2

  6. XM_054347594.1 → XP_054203569.1  fibronectin type III domain-containing protein 3B isoform X1

  7. XM_054347599.1 → XP_054203574.1  fibronectin type III domain-containing protein 3B isoform X2

  8. XM_054347592.1 → XP_054203567.1  fibronectin type III domain-containing protein 3B isoform X1

  9. XM_054347595.1 → XP_054203570.1  fibronectin type III domain-containing protein 3B isoform X1

  10. XM_054347593.1 → XP_054203568.1  fibronectin type III domain-containing protein 3B isoform X1

  11. XM_054347600.1 → XP_054203575.1  fibronectin type III domain-containing protein 3B isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q53EP0.2 GenPept UniProtKB/Swiss-Prot:Q53EP0

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