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FNDC3B fibronectin type III domain containing 3B [ Homo sapiens (human) ]

Gene ID: 64778, updated on 6-Oct-2024

Summary

Official Symbol
FNDC3Bprovided by HGNC
Official Full Name
fibronectin type III domain containing 3Bprovided by HGNC
Primary source
HGNC:HGNC:24670
See related
Ensembl:ENSG00000075420 MIM:611909; AllianceGenome:HGNC:24670
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAD104; PRO4979; YVTM2421
Summary
Enables RNA binding activity. Predicted to act upstream of or within several processes, including negative regulation of osteoblast differentiation; substrate adhesion-dependent cell spreading; and type II pneumocyte differentiation. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 15.6), thyroid (RPKM 11.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See FNDC3B in Genome Data Viewer
Location:
3q26.31
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (172039578..172401669)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (174823628..175186764)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (171757368..172119459)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TMEM212 antisense RNA 1 Neighboring gene uncharacterized LOC105374218 Neighboring gene uncharacterized LOC105374217 Neighboring gene Sharpr-MPRA regulatory region 13471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:171678336-171678836 Neighboring gene FOXA motif-containing MPRA enhancer 130 Neighboring gene NANOG hESC enhancer GRCh37_chr3:171727625-171728138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20816 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:171757188-171757855 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:171757856-171758522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20817 Neighboring gene HNF1 motif-containing MPRA enhancer 67 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20820 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:171854185-171855008 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:171858305-171859128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20821 Neighboring gene Sharpr-MPRA regulatory region 1756 Neighboring gene uncharacterized LOC124906304 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:171884751-171885290 Neighboring gene Sharpr-MPRA regulatory region 4529 Neighboring gene Sharpr-MPRA regulatory region 6188 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:171911885-171912075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:171927153-171927716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:171927717-171928279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20825 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:171940563-171941066 Neighboring gene Sharpr-MPRA regulatory region 15581 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:171973898-171974093 Neighboring gene RPS27A pseudogene 8 Neighboring gene RNA, 7SL, cytoplasmic 141, pseudogene Neighboring gene Sharpr-MPRA regulatory region 14584 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:172018611-172019279 Neighboring gene Sharpr-MPRA regulatory region 11565 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:172032476-172033374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:172165405-172166172 Neighboring gene basic leucine zipper and W2 domains 1 pseudogene 1 Neighboring gene growth hormone secretagogue receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
EBI GWAS Catalog
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ23399, MGC10002, DKFZp762K137, DKFZp686D14170

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fibronectin type III domain-containing protein 3B
Names
HCV NS5A-binding protein 37
factor for adipocyte differentiation 104

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135095.2NP_001128567.1  fibronectin type III domain-containing protein 3B

    See identical proteins and their annotated locations for NP_001128567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AB098597, AC069259, AC069523, AI417065, AK223599, AK314478
    Consensus CDS
    CCDS3217.1
    UniProtKB/Swiss-Prot
    B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
    Related
    ENSP00000338523.4, ENST00000336824.8
    Conserved Domains (2) summary
    cd00063
    Location:572666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:886947
    fn3; Fibronectin type III domain
  2. NM_022763.4NP_073600.3  fibronectin type III domain-containing protein 3B

    See identical proteins and their annotated locations for NP_073600.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AB098597, AC069259, AC069523, AI417065, AK223599, AK314478
    Consensus CDS
    CCDS3217.1
    UniProtKB/Swiss-Prot
    B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
    Related
    ENSP00000411242.2, ENST00000415807.7
    Conserved Domains (2) summary
    cd00063
    Location:572666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:886947
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    172039578..172401669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007062.2XP_016862551.1  fibronectin type III domain-containing protein 3B isoform X2

  2. XM_017007064.3XP_016862553.1  fibronectin type III domain-containing protein 3B isoform X3

  3. XM_024453717.2XP_024309485.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
    Conserved Domains (2) summary
    cd00063
    Location:572666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:886947
    fn3; Fibronectin type III domain
  4. XM_047448756.1XP_047304712.1  fibronectin type III domain-containing protein 3B isoform X2

  5. XM_047448755.1XP_047304711.1  fibronectin type III domain-containing protein 3B isoform X2

  6. XM_047448752.1XP_047304708.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
  7. XM_047448754.1XP_047304710.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
  8. XM_047448757.1XP_047304713.1  fibronectin type III domain-containing protein 3B isoform X2

  9. XM_024453716.2XP_024309484.1  fibronectin type III domain-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
    Related
    ENSP00000389094.1, ENST00000416957.5
    Conserved Domains (2) summary
    cd00063
    Location:572666
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:886947
    fn3; Fibronectin type III domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    174823628..175186764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347596.1XP_054203571.1  fibronectin type III domain-containing protein 3B isoform X2

  2. XM_054347601.1XP_054203576.1  fibronectin type III domain-containing protein 3B isoform X3

  3. XM_054347591.1XP_054203566.1  fibronectin type III domain-containing protein 3B isoform X1

  4. XM_054347598.1XP_054203573.1  fibronectin type III domain-containing protein 3B isoform X2

  5. XM_054347597.1XP_054203572.1  fibronectin type III domain-containing protein 3B isoform X2

  6. XM_054347594.1XP_054203569.1  fibronectin type III domain-containing protein 3B isoform X1

  7. XM_054347599.1XP_054203574.1  fibronectin type III domain-containing protein 3B isoform X2

  8. XM_054347592.1XP_054203567.1  fibronectin type III domain-containing protein 3B isoform X1

  9. XM_054347595.1XP_054203570.1  fibronectin type III domain-containing protein 3B isoform X1

  10. XM_054347593.1XP_054203568.1  fibronectin type III domain-containing protein 3B isoform X1

  11. XM_054347600.1XP_054203575.1  fibronectin type III domain-containing protein 3B isoform X4