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Kgd4 alpha-ketoglutarate dehydrogenase subunit 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294696, updated on 17-Aug-2024

Summary

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Official Symbol
Kgd4provided by RGD
Official Full Name
alpha-ketoglutarate dehydrogenase subunit 4provided by RGD
Primary source
RGD:1309315
See related
EnsemblRapid:ENSRNOG00000061213 AllianceGenome:RGD:1309315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mrps36
Summary
Predicted to be located in mitochondrion. Predicted to be part of mitochondrial small ribosomal subunit. Orthologous to human MRPS36 (mitochondrial ribosomal protein S36). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 759.4), Muscle (RPKM 498.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (33604611..33614988, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (31870549..31878335, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (30740620..30750916, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 125 Neighboring gene cyclin-dependent kinase 7 Neighboring gene KtI12 chromatin associated, pseudogene 1 Neighboring gene uncharacterized LOC134485587 Neighboring gene centromere protein H

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. Cavdar Koc E, et al. J Biol Chem, 2001 Jun 1. PMID 11279123
  2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of oxoglutarate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-ketoglutarate dehydrogenase component 4
Names
28S ribosomal protein S36, mitochondrial
mitochondrial ribosomal protein S36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191605.3 → NP_001178534.1  alpha-ketoglutarate dehydrogenase component 4

    See identical proteins and their annotated locations for NP_001178534.1

    Status: VALIDATED

    Source sequence(s)
    AI070491, FM072467, FQ224224
    UniProtKB/TrEMBL
    A6I5A6, M0R776
    Conserved Domains (1) summary
    pfam10937
    Location:80 → 101
    DUF2638; Protein of unknown function (DUF2638)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    33604611..33614988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281501.1 → XP_063137571.1  alpha-ketoglutarate dehydrogenase component 4 isoform X1

    Related
    ENSRNOP00000090399.2, ENSRNOT00000095661.2

  2. XM_063281502.1 → XP_063137572.1  alpha-ketoglutarate dehydrogenase component 4 isoform X2

    UniProtKB/TrEMBL
    M0R776
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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