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Ankra2 ankyrin repeat family A member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294679, updated on 17-Aug-2024

Summary

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Symbol
Ankra2provided by RGD
Full Name
ankyrin repeat family A member 2provided by RGD
Primary source
RGD:1303108
See related
EnsemblRapid:ENSRNOG00000048118 AllianceGenome:RGD:1303108
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ANKRA
Summary
Predicted to enable enzyme binding activity and low-density lipoprotein particle receptor binding activity. Predicted to be involved in regulation of gene expression and regulation of protein-containing complex assembly. Predicted to be located in cytosol and membrane. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human ANKRA2 (ankyrin repeat family A member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 70.9), Kidney (RPKM 65.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (31347158..31358002)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (29612867..29623748)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (82407601..82418229, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485583 Neighboring gene UTP15, small subunit processome component Neighboring gene uncharacterized LOC120100679 Neighboring gene basic transcription factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and functional characterization of ankyrin-repeat family protein ANKRA as a protein interacting with BKCa channel. Lim HH, et al. Mol Biol Cell, 2005 Mar. PMID 15616191, Free PMC Article
  2. Characterization of ANKRA, a novel ankyrin repeat protein that interacts with the cytoplasmic domain of megalin. Rader K, et al. J Am Soc Nephrol, 2000 Dec. PMID 11095640
  3. Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. Xu C, et al. Sci Signal, 2012 May 29. PMID 22649097
  4. Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK. McKinsey TA, et al. Mol Biol Cell, 2006 Jan. PMID 16236793, Free PMC Article
  5. Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8. Nie J, et al. Structure, 2015 Apr 7. PMID 25752541

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ANKRA could modulate the excitability of neurons by binding directly to endogenous BKCa channel and altering its gating kinetics in a calcium-dependent manner
    Title: Identification and functional characterization of ankyrin-repeat family protein ANKRA as a protein interacting with BKCa channel.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC94130

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of 3M complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat family A protein 2
Names
SLO-interacting ankyrin-containing protein
ankyrin repeat family A protein 2-like
ankyrin repeat, family A (RFXANK-like), 2
ankyrin-repeat family A protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416756.1 → NP_001403685.1  ankyrin repeat family A protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6I538, A6I539

  2. NM_207595.2 → NP_997478.1  ankyrin repeat family A protein 2 isoform 1

    See identical proteins and their annotated locations for NP_997478.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    M0R870, Q6Q287
    Related
    ENSRNOP00000107996.1, ENSRNOT00000147507.1
    Conserved Domains (2) summary
    sd00045
    Location:181 → 212
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:186 → 276
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    31347158..31358002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101921.2 → XP_038957849.1  ankyrin repeat family A protein 2 isoform X2

    Conserved Domains (3) summary
    COG0666
    Location:52 → 252
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:128 → 159
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:133 → 223
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_063281493.1 → XP_063137563.1  ankyrin repeat family A protein 2 isoform X1

    Related
    ENSRNOP00000098976.1, ENSRNOT00000136863.1

  3. XM_063281494.1 → XP_063137564.1  ankyrin repeat family A protein 2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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