U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Enc1 ectodermal-neural cortex 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294674, updated on 17-Aug-2024

Summary

Official Symbol
Enc1provided by RGD
Official Full Name
ectodermal-neural cortex 1provided by RGD
Primary source
RGD:1303152
See related
EnsemblRapid:ENSRNOG00000016541 AllianceGenome:RGD:1303152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nrpb
Summary
Predicted to enable actin binding activity. Involved in positive regulation of neuron projection development. Located in chromatin; neuronal cell body; and nuclear lumen. Orthologous to human ENC1 (ectodermal-neural cortex 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 668.1), Heart (RPKM 77.8) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
2q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (30285274..30297194)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (28550670..28562591)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (28049217..28061023)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene GTP dependent ribosome recycling factor mitochondrial 2 Neighboring gene uncharacterized LOC120100676 Neighboring gene hexosaminidase subunit beta Neighboring gene uncharacterized LOC120100677 Neighboring gene uncharacterized LOC134485824

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General protein information

Preferred Names
ectoderm-neural cortex protein 1
Names
nuclear restrict protein in brain

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003401.2NP_001003401.1  ectoderm-neural cortex protein 1

    See identical proteins and their annotated locations for NP_001003401.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I5Y5L9, Q2V9T0, Q6DKY8
    Related
    ENSRNOP00000022144.3, ENSRNOT00000022144.7
    Conserved Domains (6) summary
    smart00612
    Location:389441
    Kelch; Kelch domain
    PHA03098
    Location:48566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330374
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:36140
    BTB; BTB/POZ domain
    pfam01344
    Location:329374
    Kelch_1; Kelch motif
    pfam07707
    Location:149251
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    30285274..30297194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281492.1XP_063137562.1  ectoderm-neural cortex protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y5L9, Q2V9T0, Q6DKY8
    Related
    ENSRNOP00000079907.1, ENSRNOT00000106862.2