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Cdc37l1 cell division cycle 37-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293886, updated on 5-Mar-2024

Summary

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Official Symbol
Cdc37l1provided by RGD
Official Full Name
cell division cycle 37-like 1provided by RGD
Primary source
RGD:1309295
See related
Ensembl:ENSRNOG00000010967 AllianceGenome:RGD:1309295
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cdc37l
Summary
Predicted to enable chaperone binding activity; heat shock protein binding activity; and unfolded protein binding activity. Predicted to be involved in protein folding and protein stabilization. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human CDC37L1 (cell division cycle 37 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 170.2), Muscle (RPKM 164.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q52
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (236118630..236147527)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (226705019..226733994)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (247110147..247139113)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 6-like Neighboring gene phospholipid phosphatase 6 Neighboring gene phytanoyl-CoA 2-hydroxylase, pseudogene 1 Neighboring gene tektin 5 like 1 Neighboring gene adenylate kinase 3 Neighboring gene uncharacterized LOC120100015

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37. Scholz GM, et al. J Biol Chem, 2001 Aug 17. PMID 11413142
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hsp90 co-chaperone Cdc37-like 1
Names
cell division cycle 37 homolog-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011941.1 → NP_001011941.1  hsp90 co-chaperone Cdc37-like 1

    See identical proteins and their annotated locations for NP_001011941.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083761
    UniProtKB/Swiss-Prot
    Q5XIC3
    UniProtKB/TrEMBL
    A0A8I5YCE5, A6I0U9
    Related
    ENSRNOP00000016000.4, ENSRNOT00000016000.6
    Conserved Domains (2) summary
    smart01070
    Location:145 → 277
    CDC37_M; Cdc37 Hsp90 binding domain
    cl03951
    Location:71 → 139
    CDC37_N; Cdc37 N terminal kinase binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    236118630..236147527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589033.3 → XP_017444522.1  hsp90 co-chaperone Cdc37-like 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYM6, A0A8I5YCE5, A6I0V0
    Related
    ENSRNOP00000070715.1

  2. XM_017589034.3 → XP_017444523.1  hsp90 co-chaperone Cdc37-like 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5YCE5, A0A8I6G803
    Related
    ENSRNOP00000081457.1
    Conserved Domains (2) summary
    smart01070
    Location:145 → 277
    CDC37_M; Cdc37 Hsp90 binding domain
    cl03951
    Location:71 → 139
    CDC37_N; Cdc37 N terminal kinase binding

  3. XM_039108842.2 → XP_038964770.1  hsp90 co-chaperone Cdc37-like 1 isoform X5

    Conserved Domains (1) summary
    smart01070
    Location:44 → 183
    CDC37_M; Cdc37 Hsp90 binding domain

  4. XM_039108840.2 → XP_038964768.1  hsp90 co-chaperone Cdc37-like 1 isoform X3

    Conserved Domains (1) summary
    smart01070
    Location:44 → 183
    CDC37_M; Cdc37 Hsp90 binding domain

  5. XM_063287021.1 → XP_063143091.1  hsp90 co-chaperone Cdc37-like 1 isoform X4

RNA

  1. XR_005503952.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIC3.1 GenPept UniProtKB/Swiss-Prot:Q5XIC3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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