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CDC37L1 cell division cycle 37 like 1 [ Homo sapiens (human) ]

Gene ID: 55664, updated on 6-May-2021

Summary

Official Symbol
CDC37L1provided by HGNC
Official Full Name
cell division cycle 37 like 1provided by HGNC
Primary source
HGNC:HGNC:17179
See related
Ensembl:ENSG00000106993 MIM:610346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HARC; CDC37B
Summary
CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in liver (RPKM 13.5), heart (RPKM 8.3) and 25 other tissues See more
Orthologs
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Genomic context

See CDC37L1 in Genome Data Viewer
Location:
9p24.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (4679569..4708399)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (4679569..4708399)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 6 like Neighboring gene CDC37L1 divergent transcript Neighboring gene phospholipid phosphatase 6 Neighboring gene adenylate kinase 3 Neighboring gene extracellular matrix protein 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20639

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in platelet degranulation TAS
Traceable Author Statement
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in platelet dense granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
hsp90 co-chaperone Cdc37-like 1
Names
CDC37 cell division cycle 37 homolog-like 1
Hsp90-associating relative of Cdc37
cell division cycle 37 homolog-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017913.4NP_060383.2  hsp90 co-chaperone Cdc37-like 1

    See identical proteins and their annotated locations for NP_060383.2

    Status: VALIDATED

    Source sequence(s)
    AL136231, BC014133, DA180237
    Consensus CDS
    CCDS6454.1
    UniProtKB/Swiss-Prot
    Q7L3B6
    Related
    ENSP00000371278.3, ENST00000381854.4
    Conserved Domains (2) summary
    smart01070
    Location:138282
    CDC37_M; Cdc37 Hsp90 binding domain
    cl03951
    Location:71139
    CDC37_N; Cdc37 N terminal kinase binding

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    4679569..4708399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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