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Ggn gametogenetin [ Rattus norvegicus (Norway rat) ]

Gene ID: 292765, updated on 25-Apr-2024

Summary

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Official Symbol
Ggnprovided by RGD
Official Full Name
gametogenetinprovided by RGD
Primary source
RGD:1306765
See related
Ensembl:ENSRNOG00000023931 AllianceGenome:RGD:1306765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Predicted to act upstream of or within several processes, including double-strand break repair; embryo implantation; and gamete generation. Predicted to be located in nucleolus and perinuclear region of cytoplasm. Orthologous to human GGN (gametogenetin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 65.5), Kidney (RPKM 13.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ggn in Genome Data Viewer
Location:
1q21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93598076..93601598)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84470488..84474120)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (88112873..88116990)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene large ribosomal subunit protein eL27-like Neighboring gene RAS guanyl releasing protein 4 Neighboring gene family with sequence similarity 98, member C Neighboring gene sprouty-related, EVH1 domain containing 3 Neighboring gene proteasome 26S subunit, non-ATPase 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease. Hansson AS, et al. Am J Pathol, 2004 Mar. PMID 14982849, Free PMC Article
  2. Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. Lu B, et al. J Biol Chem, 2003 May 2. PMID 12574169
  3. Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse. Jamsai D, et al. PLoS One, 2013. PMID 23451117, Free PMC Article
  4. Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. Zhang J, et al. FEBS Lett, 2005 Jan 17. PMID 15642376
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryo implantation ISO
Inferred from Sequence Orthology
more info
  
involved_in gamete generation IEA
Inferred from Electronic Annotation
more info
  
involved_in gamete generation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gametogenetin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013065.1 → NP_001013083.2  gametogenetin isoform 1

    See identical proteins and their annotated locations for NP_001013083.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer tanscript and encodes the longer isoform (1).
    Source sequence(s)
    BC081922
    UniProtKB/TrEMBL
    A0A8I5ZK25, A0A8L2QQF7
    Related
    ENSRNOP00000053791.4, ENSRNOT00000056955.3
    Conserved Domains (1) summary
    pfam15685
    Location:38 → 693
    GGN; Gametogenetin

  2. NM_001309827.1 → NP_001296756.1  gametogenetin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' structure, resulting in the use of an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus, and is shorter than isoform 1.
    Source sequence(s)
    BC100147
    UniProtKB/TrEMBL
    A0A8I5ZK25, A0A8I5ZZG9
    Related
    ENSRNOP00000084496.1, ENSRNOT00000116194.1
    Conserved Domains (1) summary
    pfam15685
    Location:15 → 670
    GGN; Gametogenetin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    93598076..93601598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228719.5 → XP_006228781.1  gametogenetin isoform X1

    See identical proteins and their annotated locations for XP_006228781.1

    UniProtKB/Swiss-Prot
    Q66HC8
    UniProtKB/TrEMBL
    A0A8I5ZK25
    Conserved Domains (1) summary
    pfam15685
    Location:2 → 657
    GGN; Gametogenetin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HC8.1 GenPept UniProtKB/Swiss-Prot:Q66HC8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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