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Thoc1 THO complex subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291797, updated on 17-Aug-2024

Summary

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Official Symbol
Thoc1provided by RGD
Official Full Name
THO complex subunit 1provided by RGD
Primary source
RGD:1308657
See related
EnsemblRapid:ENSRNOG00000015332 AllianceGenome:RGD:1308657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LRRGT00070
Summary
Predicted to be involved in several processes, including negative regulation of DNA damage checkpoint; regulation of nucleobase-containing compound metabolic process; and viral mRNA export from host cell nucleus. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Orthologous to human THOC1 (THO complex 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 137.7), Testes (RPKM 125.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18p13
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (1253041..1291956)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (983824..1019123)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (1142540..1177084)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene collectin sub-family member 12 Neighboring gene RNA binding motif, single stranded interacting protein 2, pseudogene 1 Neighboring gene uncharacterized LOC134482897 Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component, pseudogene 2 Neighboring gene ubiquitin specific peptidase 14 Neighboring gene NDUFA4, mitochondrial complex associated, pseudogene 2 Neighboring gene Rho-associated coiled-coil containing protein kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm. Gasparri F, et al. FEBS Lett, 2004 Sep 10. PMID 15358532
  2. Apoptosis induced by the nuclear death domain protein p84N5 is inhibited by association with Rb protein. Doostzadeh-Cizeron J, et al. Mol Biol Cell, 1999 Oct. PMID 10512864, Free PMC Article
  3. Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors. Li Y, et al. Mol Cell Biol, 2005 May. PMID 15870275, Free PMC Article
  4. Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. Domínguez-Sánchez MS, et al. PLoS Genet, 2011 Dec. PMID 22144908, Free PMC Article
  5. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Guo S, et al. Cancer Res, 2005 Apr 15. PMID 15833825

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of THO complex ISO
Inferred from Sequence Orthology
more info
  
part_of THO complex part of transcription export complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription export complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
THO complex subunit 1
Names
THO complex 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001047850.2 → NP_001041315.1  THO complex subunit 1 isoform 2

    See identical proteins and their annotated locations for NP_001041315.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    Q6TUH4
    Related
    ENSRNOP00000079602.1, ENSRNOT00000113760.2
    Conserved Domains (2) summary
    cd08318
    Location:407 → 492
    Death_NMPP84; Death domain of Nuclear Matrix Protein P84
    pfam11957
    Location:29 → 381
    efThoc1; THO complex subunit 1 transcription elongation factor

  2. NM_001398637.1 → NP_001385566.1  THO complex subunit 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6KND6, F7FH27
    Related
    ENSRNOP00000101408.1, ENSRNOT00000149022.1
    Conserved Domains (2) summary
    cd08318
    Location:565 → 650
    Death_NMPP84; Death domain of Nuclear Matrix Protein P84
    pfam11957
    Location:74 → 539
    efThoc1; THO complex subunit 1 transcription elongation factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    1253041..1291956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277273.1 → XP_063133343.1  THO complex subunit 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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