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THOC1 THO complex 1 [ Homo sapiens (human) ]

Gene ID: 9984, updated on 21-Dec-2019

Summary

Official Symbol
THOC1provided by HGNC
Official Full Name
THO complex 1provided by HGNC
Primary source
HGNC:HGNC:19070
See related
Ensembl:ENSG00000079134 MIM:606930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P84; HPR1; P84N5
Summary
HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in testis (RPKM 6.7), bone marrow (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See THOC1 in Genome Data Viewer
Location:
18p11.32
Exon count:
23
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (214348..268047, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (214520..268059, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene Rho associated coiled-coil containing protein kinase 1 pseudogene 1 Neighboring gene microRNA 8078 Neighboring gene uncharacterized LOC105371951 Neighboring gene ubiquitin specific peptidase 14 Neighboring gene collectin subfamily member 12 Neighboring gene uncharacterized LOC107985155 Neighboring gene long intergenic non-protein coding RNA 1925

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA export from nucleus TAS
Traceable Author Statement
more info
 
RNA processing TAS
Traceable Author Statement
more info
PubMed 
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
negative regulation of DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of isotype switching to IgA isotypes ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of DNA-templated transcription, elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of DNA recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of DNA-templated transcription, elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of DNA-templated transcription, elongation IDA
Inferred from Direct Assay
more info
PubMed 
replication fork processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
viral mRNA export from host cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
THO complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
THO complex IDA
Inferred from Direct Assay
more info
PubMed 
THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
THO complex part of transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
colocalizes_with nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription export complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
THO complex subunit 1
Names
hTREX84
nuclear matrix protein p84
tho1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005131.3NP_005122.2  THO complex subunit 1

    See identical proteins and their annotated locations for NP_005122.2

    Status: VALIDATED

    Source sequence(s)
    AK225709, AP000845, BC010381, DA902294
    Consensus CDS
    CCDS45820.1
    UniProtKB/Swiss-Prot
    Q96FV9
    Related
    ENSP00000261600.6, ENST00000261600.11
    Conserved Domains (2) summary
    cd08318
    Location:565650
    Death_NMPP84; Death domain of Nuclear Matrix Protein P84
    pfam11957
    Location:74539
    efThoc1; THO complex subunit 1 transcription elongation factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    214348..268047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525772.3XP_011524074.1  THO complex subunit 1 isoform X1

    Conserved Domains (2) summary
    cd08318
    Location:572657
    Death_NMPP84; Death domain of Nuclear Matrix Protein P84
    pfam11957
    Location:74546
    efThoc1; THO complex subunit 1 transcription elongation factor
  2. XM_011525773.1XP_011524075.1  THO complex subunit 1 isoform X2

    Conserved Domains (2) summary
    cd08318
    Location:434519
    Death_NMPP84; Death domain of Nuclear Matrix Protein P84
    pfam11957
    Location:1408
    efThoc1; THO complex subunit 1 transcription elongation factor
  3. XM_024451292.1XP_024307060.1  THO complex subunit 1 isoform X4

    Conserved Domains (2) summary
    cd08318
    Location:258343
    Death_NMPP84; Death domain of Nuclear Matrix Protein P84
    pfam11957
    Location:1232
    efThoc1; THO complex subunit 1 transcription elongation factor
  4. XM_011525774.2XP_011524076.1  THO complex subunit 1 isoform X3

    Conserved Domains (2) summary
    cd08318
    Location:265350
    Death_NMPP84; Death domain of Nuclear Matrix Protein P84
    pfam11957
    Location:1239
    efThoc1; THO complex subunit 1 transcription elongation factor
  5. XM_017026104.2XP_016881593.1  THO complex subunit 1 isoform X5

    Related
    ENSP00000462757.1, ENST00000580038.5
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