RACGAP1 Rac GTPase activating protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RACGAP1provided by HGNC
Official Full Name: Rac GTPase activating protein 1provided by HGNC
Primary source: HGNC:HGNC:9804
See related: Ensembl:ENSG00000161800 MIM:604980; AllianceGenome:HGNC:9804
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CYK4; CDAN3B; ID-GAP; HsCYK-4; MgcRacGAP
Summary: This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016]
Expression: Broad expression in testis (RPKM 17.3), bone marrow (RPKM 8.3) and 20 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12q13.12

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (49989162..50033440, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (49952172..49996504, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (50382945..50419277, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RACGAP1 drives proliferation, migration and invasion and suppresses autophagy of gastric cancer cells via inhibiting SIRT1/Mfn2.
Title: RACGAP1 drives proliferation, migration and invasion and suppresses autophagy of gastric cancer cells via inhibiting SIRT1/Mfn2.
FOXM1 transcriptional regulation of RacGAP1 activates the PI3K/AKT signaling pathway to promote the proliferation, migration, and invasion of cervical cancer cells.
Title: FOXM1 transcriptional regulation of RacGAP1 activates the PI3K/AKT signaling pathway to promote the proliferation, migration, and invasion of cervical cancer cells.
Oncogenic and immunological roles of RACGAP1 in pan-cancer and its potential value in nasopharyngeal carcinoma.
Title: Oncogenic and immunological roles of RACGAP1 in pan-cancer and its potential value in nasopharyngeal carcinoma.
m6A-modified circASXL1 promotes proliferation and migration of ovarian cancer through the miR-320d/RACGAP1 axis.
Title: m6A-modified circASXL1 promotes proliferation and migration of ovarian cancer through the miR-320d/RACGAP1 axis.
RACGAP1 promotes the progression and poor prognosis of lung adenocarcinoma through its effects on the cell cycle and tumor stemness.
Title: RACGAP1 promotes the progression and poor prognosis of lung adenocarcinoma through its effects on the cell cycle and tumor stemness.
Racgap1 knockdown results in cells with multiple cilia due to cytokinesis failure.
Title: Racgap1 knockdown results in cells with multiple cilia due to cytokinesis failure.
Mutations in the RACGAP1 gene cause autosomal recessive congenital dyserythropoietic anemia type III.
Title: Mutations in the RACGAP1 gene cause autosomal recessive congenital dyserythropoietic anemia type III.
Assessment of RACGAP1 as a Prognostic and Immunological Biomarker in Multiple Human Tumors: A Multiomics Analysis.
Title: Assessment of RACGAP1 as a Prognostic and Immunological Biomarker in Multiple Human Tumors: A Multiomics Analysis.
Up-Regulation of RACGAP1 Promotes Progressions of Hepatocellular Carcinoma Regulated by GABPA via PI3K/AKT Pathway.
Title: Up-Regulation of RACGAP1 Promotes Progressions of Hepatocellular Carcinoma Regulated by GABPA via PI3K/AKT Pathway.
LncRNA PART1 Stimulates the Development of Ovarian Cancer by Up-regulating RACGAP1 and RRM2.
Title: LncRNA PART1 Stimulates the Development of Ovarian Cancer by Up-regulating RACGAP1 and RRM2.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Anemia, congenital dyserythropoietic, type IIIb, autosomal recessive MedGen: C5676940 OMIM: 619789 GeneReviews: Not available	Compare labs

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction	Pubs
Knockdown of Rac GTPase activating protein 1 (RACGAP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RACGAP1_9584 (e-PCR)
- UniSTS:468633

WI-17598 (e-PCR)
- UniSTS:42403

STS-W72501 (e-PCR)
- UniSTS:25803

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activator activity	TAS Traceable Author Statement more info
enables alpha-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables gamma-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin contractile ring assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IC Inferred by Curator more info	PubMed
involved_in mitotic cytokinesis	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle midzone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle midzone assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in neuroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokinesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of attachment of spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of embryonic development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in sulfate transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
part_of centralspindlin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of centralspindlin complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cleavage furrow	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: rac GTPase-activating protein 1

Names: male germ cell RacGap; protein CYK4 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126103.3 → NP_001119575.1 rac GTPase-activating protein 1 isoform a

See identical proteins and their annotated locations for NP_001119575.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon and contains an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).

Source sequence(s)

AC025154

Consensus CDS

CCDS8795.1

UniProtKB/Swiss-Prot

Q6PJ26, Q9H0H5, Q9NWN2, Q9P250, Q9P2W2

UniProtKB/TrEMBL

B2RE34

Related

ENSP00000449370.1, ENST00000547905.5

Conserved Domains (3) summary

cd00029
Location:287 → 335

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:346 → 539

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

cl25732
Location:13 → 105

SMC_N; RecF/RecN/SMC N terminal domain
NM_001126104.3 → NP_001119576.1 rac GTPase-activating protein 1 isoform a

See identical proteins and their annotated locations for NP_001119576.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two exons and uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).

Source sequence(s)

AC025154

Consensus CDS

CCDS8795.1

UniProtKB/Swiss-Prot

Q6PJ26, Q9H0H5, Q9NWN2, Q9P250, Q9P2W2

UniProtKB/TrEMBL

B2RE34

Related

ENSP00000404808.2, ENST00000454520.6

Conserved Domains (3) summary

cd00029
Location:287 → 335

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:346 → 539

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

cl25732
Location:13 → 105

SMC_N; RecF/RecN/SMC N terminal domain
NM_001319999.2 → NP_001306928.1 rac GTPase-activating protein 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two exons in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).

Source sequence(s)

AC025154

Consensus CDS

CCDS8795.1

UniProtKB/Swiss-Prot

Q6PJ26, Q9H0H5, Q9NWN2, Q9P250, Q9P2W2

UniProtKB/TrEMBL

B2RE34

Related

ENSP00000309871.5, ENST00000312377.10

Conserved Domains (3) summary

cd00029
Location:287 → 335

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:346 → 539

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

cl25732
Location:13 → 105

SMC_N; RecF/RecN/SMC N terminal domain
NM_001320000.2 → NP_001306929.1 rac GTPase-activating protein 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two exons and contains an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).

Source sequence(s)

AC025154

Consensus CDS

CCDS8795.1

UniProtKB/Swiss-Prot

Q6PJ26, Q9H0H5, Q9NWN2, Q9P250, Q9P2W2

UniProtKB/TrEMBL

B2RE34

Conserved Domains (3) summary

cd00029
Location:287 → 335

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:346 → 539

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

cl25732
Location:13 → 105

SMC_N; RecF/RecN/SMC N terminal domain
NM_001320001.2 → NP_001306930.1 rac GTPase-activating protein 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks two exons and uses two alternate splice sites in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).

Source sequence(s)

AC025154

Consensus CDS

CCDS8795.1

UniProtKB/Swiss-Prot

Q6PJ26, Q9H0H5, Q9NWN2, Q9P250, Q9P2W2

UniProtKB/TrEMBL

B2RE34

Conserved Domains (3) summary

cd00029
Location:287 → 335

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:346 → 539

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

cl25732
Location:13 → 105

SMC_N; RecF/RecN/SMC N terminal domain
NM_001320002.2 → NP_001306931.1 rac GTPase-activating protein 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks two exons and uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).

Source sequence(s)

AC025154

Consensus CDS

CCDS8795.1

UniProtKB/Swiss-Prot

Q6PJ26, Q9H0H5, Q9NWN2, Q9P250, Q9P2W2

UniProtKB/TrEMBL

B2RE34

Conserved Domains (3) summary

cd00029
Location:287 → 335

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:346 → 539

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

cl25732
Location:13 → 105

SMC_N; RecF/RecN/SMC N terminal domain
NM_001320003.2 → NP_001306932.1 rac GTPase-activating protein 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks two exons and uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).

Source sequence(s)

AC025154

Consensus CDS

CCDS8795.1

UniProtKB/Swiss-Prot

Q6PJ26, Q9H0H5, Q9NWN2, Q9P250, Q9P2W2

UniProtKB/TrEMBL

B2RE34

Conserved Domains (3) summary

cd00029
Location:287 → 335

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:346 → 539

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

cl25732
Location:13 → 105

SMC_N; RecF/RecN/SMC N terminal domain
NM_001320004.2 → NP_001306933.1 rac GTPase-activating protein 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (9) lacks two exons and uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).

Source sequence(s)

AC025154

Consensus CDS

CCDS8795.1

UniProtKB/Swiss-Prot

Q6PJ26, Q9H0H5, Q9NWN2, Q9P250, Q9P2W2

UniProtKB/TrEMBL

B2RE34

Conserved Domains (3) summary

cd00029
Location:287 → 335

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:346 → 539

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

cl25732
Location:13 → 105

SMC_N; RecF/RecN/SMC N terminal domain
NM_001320005.2 → NP_001306934.1 rac GTPase-activating protein 1 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (10) lacks three exons in the 5' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a.

Source sequence(s)

AC025154

UniProtKB/TrEMBL

B2RE34

Conserved Domains (2) summary

cd00029
Location:229 → 277

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:288 → 481

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
NM_001320006.2 → NP_001306935.1 rac GTPase-activating protein 1 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (11) lacks two exons, contains an alternate exon, and uses an alternate splice site in the 5' region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (c) has a longer N-terminus than isoform a.

Source sequence(s)

AC025154

UniProtKB/TrEMBL

B2RE34

Conserved Domains (2) summary

cd00029
Location:299 → 347

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:358 → 551

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
NM_001320007.2 → NP_001306936.1 rac GTPase-activating protein 1 isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (12) lacks three exons in the 5' region and initiates translation at an alternate downstream start codon compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AC025154

UniProtKB/TrEMBL

B2RE34

Conserved Domains (2) summary

cd00029
Location:213 → 261

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:272 → 465

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
NM_013277.5 → NP_037409.2 rac GTPase-activating protein 1 isoform a

See identical proteins and their annotated locations for NP_037409.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the reference variant. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 encode the same isoform (a).

Source sequence(s)

AC025154

Consensus CDS

CCDS8795.1

UniProtKB/Swiss-Prot

Q6PJ26, Q9H0H5, Q9NWN2, Q9P250, Q9P2W2

UniProtKB/TrEMBL

B2RE34

Related

ENSP00000404190.2, ENST00000427314.6

Conserved Domains (3) summary

cd00029
Location:287 → 335

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:346 → 539

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

cl25732
Location:13 → 105

SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

49989162..50033440 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024448958.2 → XP_024304726.1 rac GTPase-activating protein 1 isoform X1

UniProtKB/TrEMBL

B2RE34

Conserved Domains (3) summary

cd00029
Location:306 → 354

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:365 → 558

RhoGAP_MgcRacGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is ...

cl25732
Location:32 → 124

SMC_N; RecF/RecN/SMC N terminal domain
XM_011538238.1 → XP_011536540.1 rac GTPase-activating protein 1 isoform X3

See identical proteins and their annotated locations for XP_011536540.1

UniProtKB/Swiss-Prot

Q6PJ26, Q9H0H5, Q9NWN2, Q9P250, Q9P2W2

UniProtKB/TrEMBL

B2RE34

Related

ENSP00000449374.1, ENST00000551016.5

Conserved Domains (3) summary

cd00029
Location:287 → 335

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:346 → 539

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

cl25732
Location:13 → 105

SMC_N; RecF/RecN/SMC N terminal domain
XM_017019227.2 → XP_016874716.1 rac GTPase-activating protein 1 isoform X4

UniProtKB/TrEMBL

B2RE34

Conserved Domains (2) summary

cd00029
Location:213 → 261

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:272 → 465

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
XM_017019224.2 → XP_016874713.1 rac GTPase-activating protein 1 isoform X4

UniProtKB/TrEMBL

B2RE34

Conserved Domains (2) summary

cd00029
Location:213 → 261

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:272 → 465

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
XM_047428750.1 → XP_047284706.1 rac GTPase-activating protein 1 isoform X3

UniProtKB/Swiss-Prot

Q6PJ26, Q9H0H5, Q9NWN2, Q9P250, Q9P2W2
XM_047428748.1 → XP_047284704.1 rac GTPase-activating protein 1 isoform X2
XM_047428747.1 → XP_047284703.1 rac GTPase-activating protein 1 isoform X2
XM_047428751.1 → XP_047284707.1 rac GTPase-activating protein 1 isoform X4
XM_047428746.1 → XP_047284702.1 rac GTPase-activating protein 1 isoform X2
XM_017019225.3 → XP_016874714.1 rac GTPase-activating protein 1 isoform X4

UniProtKB/TrEMBL

B2RE34

Conserved Domains (2) summary

cd00029
Location:213 → 261

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:272 → 465

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
XM_006719359.2 → XP_006719422.1 rac GTPase-activating protein 1 isoform X3

See identical proteins and their annotated locations for XP_006719422.1

UniProtKB/Swiss-Prot

Q6PJ26, Q9H0H5, Q9NWN2, Q9P250, Q9P2W2

UniProtKB/TrEMBL

B2RE34

Conserved Domains (3) summary

cd00029
Location:287 → 335

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:346 → 539

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

cl25732
Location:13 → 105

SMC_N; RecF/RecN/SMC N terminal domain
XM_017019222.2 → XP_016874711.1 rac GTPase-activating protein 1 isoform X4

UniProtKB/TrEMBL

B2RE34

Conserved Domains (2) summary

cd00029
Location:213 → 261

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:272 → 465

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
XM_047428749.1 → XP_047284705.1 rac GTPase-activating protein 1 isoform X2
XM_017019223.3 → XP_016874712.1 rac GTPase-activating protein 1 isoform X4

UniProtKB/TrEMBL

B2RE34

Conserved Domains (2) summary

cd00029
Location:213 → 261

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:272 → 465

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
XM_017019221.2 → XP_016874710.1 rac GTPase-activating protein 1 isoform X4

UniProtKB/TrEMBL

B2RE34

Conserved Domains (2) summary

cd00029
Location:213 → 261

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:272 → 465

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
XM_047428745.1 → XP_047284701.1 rac GTPase-activating protein 1 isoform X2
XM_017019226.1 → XP_016874715.1 rac GTPase-activating protein 1 isoform X4

UniProtKB/TrEMBL

B2RE34

Conserved Domains (2) summary

cd00029
Location:213 → 261

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:272 → 465

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

49952172..49996504 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054371859.1 → XP_054227834.1 rac GTPase-activating protein 1 isoform X1
XM_054371867.1 → XP_054227842.1 rac GTPase-activating protein 1 isoform X3

UniProtKB/Swiss-Prot

Q6PJ26, Q9H0H5, Q9NWN2, Q9P250, Q9P2W2
XM_054371875.1 → XP_054227850.1 rac GTPase-activating protein 1 isoform X4
XM_054371872.1 → XP_054227847.1 rac GTPase-activating protein 1 isoform X4
XM_054371866.1 → XP_054227841.1 rac GTPase-activating protein 1 isoform X3

UniProtKB/Swiss-Prot

Q6PJ26, Q9H0H5, Q9NWN2, Q9P250, Q9P2W2
XM_054371863.1 → XP_054227838.1 rac GTPase-activating protein 1 isoform X2
XM_054371862.1 → XP_054227837.1 rac GTPase-activating protein 1 isoform X2
XM_054371874.1 → XP_054227849.1 rac GTPase-activating protein 1 isoform X4
XM_054371861.1 → XP_054227836.1 rac GTPase-activating protein 1 isoform X2
XM_054371873.1 → XP_054227848.1 rac GTPase-activating protein 1 isoform X4
XM_054371865.1 → XP_054227840.1 rac GTPase-activating protein 1 isoform X3

UniProtKB/Swiss-Prot

Q6PJ26, Q9H0H5, Q9NWN2, Q9P250, Q9P2W2
XM_054371869.1 → XP_054227844.1 rac GTPase-activating protein 1 isoform X4
XM_054371864.1 → XP_054227839.1 rac GTPase-activating protein 1 isoform X2
XM_054371870.1 → XP_054227845.1 rac GTPase-activating protein 1 isoform X4
XM_054371868.1 → XP_054227843.1 rac GTPase-activating protein 1 isoform X4
XM_054371860.1 → XP_054227835.1 rac GTPase-activating protein 1 isoform X2
XM_054371871.1 → XP_054227846.1 rac GTPase-activating protein 1 isoform X4