U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DNASE2 deoxyribonuclease 2, lysosomal [ Bos taurus (cattle) ]

Gene ID: 282218, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
DNASE2provided by VGNC
Official Full Name
deoxyribonuclease 2, lysosomalprovided by VGNC
Primary source
VGNC:VGNC:28136
See related
BGD:BT17794; Ensembl:ENSBTAG00000006082
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See DNASE2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (12676707..12679150)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene synaptonemal complex central element protein 2 Neighboring gene glutaryl-CoA dehydrogenase Neighboring gene KLF transcription factor 1 Neighboring gene microtubule associated serine/threonine kinase 1 Neighboring gene translation machinery-associated protein 7-like Neighboring gene retbindin

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The cloning and expression of human deoxyribonuclease II. A possible role in apoptosis. Krieser RJ, et al. J Biol Chem, 1998 Nov 20. PMID 9812984
  2. A family history of deoxyribonuclease II: surprises from Trichinella spiralis and Burkholderia pseudomallei. MacLea KS, et al. Gene, 2003 Feb 13. PMID 12594037
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC140819

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables deoxyribonuclease II activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic DNA fragmentation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
deoxyribonuclease-2-alpha
Names
DNase II alpha
acid DNase
deoxyribonuclease II alpha
deoxyribonuclease II, lysosomal
lysosomal DNase II
NP_001068595.1
XP_005208707.1
XP_005208709.1
XP_010805020.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075127.2 → NP_001068595.1  deoxyribonuclease-2-alpha precursor

    See identical proteins and their annotated locations for NP_001068595.1

    Status: PROVISIONAL

    Source sequence(s)
    BC118429
    UniProtKB/Swiss-Prot
    O46614, P56541, Q17QD1
    Related
    ENSBTAP00000007993.3, ENSBTAT00000007993.4
    Conserved Domains (2) summary
    pfam03265
    Location:21 → 346
    DNase_II; Deoxyribonuclease II
    cl15239
    Location:18 → 179
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    12676707..12679150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010806718.4 → XP_010805020.1  deoxyribonuclease-2-alpha isoform X1

    See identical proteins and their annotated locations for XP_010805020.1

    Conserved Domains (2) summary
    pfam03265
    Location:21 → 352
    DNase_II; Deoxyribonuclease II
    cl15239
    Location:18 → 185
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

  2. XM_005208650.5 → XP_005208707.1  deoxyribonuclease-2-alpha isoform X2

    See identical proteins and their annotated locations for XP_005208707.1

    UniProtKB/TrEMBL
    F1MZ33
    Conserved Domains (1) summary
    pfam03265
    Location:21 → 343
    DNase_II; Deoxyribonuclease II

  3. XM_005208652.5 → XP_005208709.1  deoxyribonuclease-2-alpha isoform X3

    See identical proteins and their annotated locations for XP_005208709.1

    Conserved Domains (2) summary
    pfam03265
    Location:21 → 291
    DNase_II; Deoxyribonuclease II
    cl15239
    Location:158 → 293
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56541.2 GenPept UniProtKB/Swiss-Prot:P56541

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.