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DNTT DNA nucleotidylexotransferase [ Bos taurus (domestic cattle) ]

Gene ID: 281120, updated on 17-Aug-2024

Summary

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Official Symbol
DNTTprovided by VGNC
Official Full Name
DNA nucleotidylexotransferaseprovided by VGNC
Primary source
VGNC:VGNC:28150
See related
BGD:BT11391; Ensembl:ENSBTAG00000020427
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 26
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (17644945..17677638)

Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 518A Neighboring gene B cell linker Neighboring gene oligodendrocytic myelin paranodal and inner loop protein Neighboring gene tolloid like 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquitylation of terminal deoxynucleotidyltransferase inhibits its activity. Maezawa S, et al. PLoS One, 2012. PMID 22808041, Free PMC Article
  2. Biochemistry of terminal deoxynucleotidyltransferase. Affinity labeling and identification of the deoxynucleoside triphosphate binding domain of terminal deoxynucleotidyltransferase. Pandey V, et al. J Biol Chem, 1988 Mar 15. PMID 3346221
  3. Biochemistry of terminal deoxynucleotidyltransferase. Identification and unity of ribo- and deoxyribonucleoside triphosphate binding site in terminal deoxynucleotidyltransferase. Pandey VN, et al. J Biol Chem, 1989 Jan 15. PMID 2910867
  4. Photoaffinity labeling of terminal deoxynucleotidyl transferase. 2. Identification of peptides in the nucleotide binding domain. Evans RK, et al. Biochemistry, 1989 Jan 24. PMID 2713339
  5. Molecular cloning of human terminal deoxynucleotidyltransferase. Peterson RC, et al. Proc Natl Acad Sci U S A, 1984 Jul. PMID 6087320, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitylation of terminal deoxynucleotidyltransferase inhibits its activity.
    Title: Ubiquitylation of terminal deoxynucleotidyltransferase inhibits its activity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA nucleotidylexotransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair via nonhomologous end joining IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA nucleotidylexotransferase
Names
TDT
deoxynucleotidyltransferase, terminal
terminal addition enzyme
terminal deoxynucleotidyltransferase
terminal transferase
NP_803461.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177495.2 → NP_803461.1  DNA nucleotidylexotransferase

    See identical proteins and their annotated locations for NP_803461.1

    Status: PROVISIONAL

    Source sequence(s)
    X04122
    UniProtKB/Swiss-Prot
    P06526
    UniProtKB/TrEMBL
    A0A140T8D0
    Related
    ENSBTAP00000027223.5, ENSBTAT00000027223.6
    Conserved Domains (3) summary
    cd00141
    Location:177 → 518
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    smart00292
    Location:43 → 122
    BRCT; breast cancer carboxy-terminal domain
    smart00483
    Location:174 → 519
    POLXc; DNA polymerase X family

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    17644945..17677638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06526.2 GenPept UniProtKB/Swiss-Prot:P06526

Gene LinkOut

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Molecular Biology Databases
Research Materials