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DNTT DNA nucleotidylexotransferase [ Homo sapiens (human) ]

Gene ID: 1791, updated on 7-Jun-2020

Summary

Official Symbol
DNTTprovided by HGNC
Official Full Name
DNA nucleotidylexotransferaseprovided by HGNC
Primary source
HGNC:HGNC:2983
See related
Ensembl:ENSG00000107447 MIM:187410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TDT
Summary
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward bone marrow (RPKM 10.1) See more
Orthologs

Genomic context

See DNTT in Genome Data Viewer
Location:
10q24.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (96304434..96338564)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (98064085..98098321)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 271, pseudogene Neighboring gene zinc finger protein 518A Neighboring gene nucleophosmin 1 pseudogene 25 Neighboring gene B cell linker Neighboring gene oligodendrocytic myelin paranodal and inner loop protein Neighboring gene tolloid like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA nucleotidylexotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA nucleotidylexotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
DNA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
DNA modification IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to ATP IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
euchromatin IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA nucleotidylexotransferase
Names
nucleosidetriphosphate:DNA deoxynucleotidylexotransferase
terminal addition enzyme
terminal deoxynucleotidyltransferase
terminal deoxyribonucleotidyltransferase
terminal transferase
NP_001017520.1
NP_004079.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017520.2NP_001017520.1  DNA nucleotidylexotransferase isoform 2

    See identical proteins and their annotated locations for NP_001017520.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes an isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    AK130771, AL136181, BC012920, DB110609
    Consensus CDS
    CCDS44465.1
    UniProtKB/Swiss-Prot
    P04053
    Related
    ENSP00000486733.1, ENST00000630152.1
    Conserved Domains (3) summary
    cd00141
    Location:166506
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    smart00292
    Location:32111
    BRCT; breast cancer carboxy-terminal domain
    smart00483
    Location:163507
    POLXc; DNA polymerase X family
  2. NM_004088.4NP_004079.3  DNA nucleotidylexotransferase isoform 1

    See identical proteins and their annotated locations for NP_004079.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL136181, BC012920, DB110609
    Consensus CDS
    CCDS7447.1
    UniProtKB/Swiss-Prot
    P04053
    Related
    ENSP00000360216.2, ENST00000371174.5
    Conserved Domains (3) summary
    cd00141
    Location:166507
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    smart00292
    Location:32111
    BRCT; breast cancer carboxy-terminal domain
    smart00483
    Location:163508
    POLXc; DNA polymerase X family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    96304434..96338564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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